Mycophenolate Mofetil
Mycophenolate mofetil (MMF) is an immunosuppressant prodrug of mycophenolic acid (MPA). It selectively inhibits inosine monophosphate dehydrogenase (IMPDH), an enzyme essential for the de novo synthesis of guanosine nucleotides. Since T and B lymphocytes rely solely on this pathway for proliferation, MMF effectively suppresses immune-mediated graft rejection and autoimmune flare-ups.
Dosage by Body Weight
Must be prescribed and monitored by a specialist. Usually administered twice daily on an empty stomach (1 hour before or 2 hours after meals). Swallow whole; do not crush, chew, or open capsules.
- Body Weight
- Below 5 kg
- Dose
- BSA-based calculation required
- Frequency
- Twice daily
- Tracking Notes
- Dosing is strictly determined by Body Surface Area (BSA), typically 600 mg/m² per dose. Use of liquid oral suspension is required.
- Body Weight
- 5-7 kg
- Dose
- Approximately 75 mg to 100 mg
- Frequency
- Twice daily
- Tracking Notes
- Must be calculated using BSA (600 mg/m² per dose). Monitor complete blood counts regularly due to risk of neutropenia.
- Body Weight
- 8-10 kg
- Dose
- Approximately 120 mg to 150 mg
- Frequency
- Twice daily
- Tracking Notes
- Dose adjusted based on target blood levels and clinical response. Use oral suspension for accurate measurement.
- Body Weight
- 11-15 kg
- Dose
- Approximately 180 mg to 250 mg
- Frequency
- Twice daily
- Tracking Notes
- Based on BSA. Avoid administration with antacids containing magnesium or aluminum, as they decrease absorption.
- Body Weight
- 16-20 kg
- Dose
- Approximately 250 mg to 300 mg
- Frequency
- Twice daily
- Tracking Notes
- Maximum pediatric dose is typically capped at 1 g twice daily (2 g/day total) unless specified by the transplant team.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | BSA-based calculation required | Twice daily | Dosing is strictly determined by Body Surface Area (BSA), typically 600 mg/m² per dose. Use of liquid oral suspension is required. |
| 5-7 kg | Approximately 75 mg to 100 mg | Twice daily | Must be calculated using BSA (600 mg/m² per dose). Monitor complete blood counts regularly due to risk of neutropenia. |
| 8-10 kg | Approximately 120 mg to 150 mg | Twice daily | Dose adjusted based on target blood levels and clinical response. Use oral suspension for accurate measurement. |
| 11-15 kg | Approximately 180 mg to 250 mg | Twice daily | Based on BSA. Avoid administration with antacids containing magnesium or aluminum, as they decrease absorption. |
| 16-20 kg | Approximately 250 mg to 300 mg | Twice daily | Maximum pediatric dose is typically capped at 1 g twice daily (2 g/day total) unless specified by the transplant team. |
Formulation
Purpose
Immunosuppressive agent used to prevent organ rejection in kidney, heart, and liver transplant recipients, and to manage active lupus nephritis and other autoimmune conditions.
Generic Name
Mycophenolate MofetilBranded Drug Names
Mycophenolate Mofetil is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.