CellCept
CellCept is a potent immunosuppressant medication. It is a prodrug of mycophenolic acid (MPA), which inhibits the enzyme inosine monophosphate dehydrogenase (IMPDH). This inhibition blocks the de novo pathway of guanosine nucleotide synthesis, which is indispensable for the proliferation of T and B lymphocytes.
Dosage by Body Weight
The standard adult dose for kidney transplant is 1 g orally or IV twice daily (2 g/day). For heart and liver transplants, the recommended dose is 1.5 g orally or IV twice daily (3 g/day). Pediatric dosing is strictly calculated based on Body Surface Area (BSA), typically 600 mg/m2 per dose twice daily.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy in pediatric patients under 3 months of age have not been established. Highly specialized dosing required.
- Body Weight
- 5-7 kg
- Dose
- BSA-dependent
- Frequency
- Twice daily
- Tracking Notes
- Must be calculated using Body Surface Area (typically 600 mg/m² per dose). Do not dose by weight alone.
- Body Weight
- 8-10 kg
- Dose
- BSA-dependent
- Frequency
- Twice daily
- Tracking Notes
- Requires liquid oral suspension. Must be prescribed and adjusted by a transplant specialist based on BSA and blood levels.
- Body Weight
- 11-15 kg
- Dose
- BSA-dependent
- Frequency
- Twice daily
- Tracking Notes
- Pediatric dosing requires close monitoring of blood counts and drug therapeutic levels.
- Body Weight
- 16-20 kg
- Dose
- BSA-dependent
- Frequency
- Twice daily
- Tracking Notes
- Usually administered as an oral suspension. Capsules or tablets should not be opened, crushed, or chewed.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Safety and efficacy in pediatric patients under 3 months of age have not been established. Highly specialized dosing required. |
| 5-7 kg | BSA-dependent | Twice daily | Must be calculated using Body Surface Area (typically 600 mg/m² per dose). Do not dose by weight alone. |
| 8-10 kg | BSA-dependent | Twice daily | Requires liquid oral suspension. Must be prescribed and adjusted by a transplant specialist based on BSA and blood levels. |
| 11-15 kg | BSA-dependent | Twice daily | Pediatric dosing requires close monitoring of blood counts and drug therapeutic levels. |
| 16-20 kg | BSA-dependent | Twice daily | Usually administered as an oral suspension. Capsules or tablets should not be opened, crushed, or chewed. |
Formulation
Purpose
Prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac, or hepatic transplants, used in combination with cyclosporine and corticosteroids.
Generic Name
Mycophenolate mofetilScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.