Methotrexate
At low doses for JIA, it acts as an anti-inflammatory and immune modulator. **Dosed ONCE WEEKLY only**.
Dosage by Body Weight
Standard JIA dose: 10–15 mg/m² (approx 0.5 mg/kg) **ONCE PER WEEK**. Give with Folic Acid to reduce mouth sores.
- Body Weight
- 15-25 kg
- Dose
- 7.5 mg to 12.5 mg
- Frequency
- Once weekly
- Tracking Notes
- Verify the weekly schedule; daily dosing can be fatal.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| 15-25 kg | 7.5 mg to 12.5 mg | Once weekly | Verify the weekly schedule; daily dosing can be fatal. |
Formulation
Purpose
Treatment of Juvenile Idiopathic Arthritis (JIA) and certain pediatric cancers.
Generic Name
MethotrexateBranded Drug Names
Methotrexate is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.
Alternatives
Safety Advice
Alcohol
CAUTIONMethotrexate: Alcohol can increase liver strain, stomach irritation, or immune-related complications. Avoid alcohol unless your specialist allows it.
Pregnancy
CAUTIONMethotrexate: Use in pregnancy only under specialist advice because immune, cancer, or transplant treatment requires careful risk assessment.
Breast Feeding
CAUTIONMethotrexate: Breastfeeding may not be recommended with some immunosuppressive or chemotherapy medicines. Follow specialist advice.
Driving
CAUTIONMethotrexate: May cause dizziness, fatigue, nausea, or weakness. Avoid driving if affected.
Liver
CAUTIONMethotrexate: Can affect liver function and usually requires regular blood tests. Use only with specialist monitoring.
Kidney
CAUTIONMethotrexate: Kidney function may need close monitoring, particularly with calcineurin inhibitors or high-risk regimens.