Mexate
Mexate contains Methotrexate, an antimetabolite and immunosuppressant. It works by inhibiting the enzyme dihydrofolate reductase, thereby preventing DNA synthesis and cell proliferation in rapidly growing tissues.
Dosage by Body Weight
Dosage must be highly individualized. For rheumatoid arthritis and psoriasis, it is typically taken ONCE WEEKLY. Daily dosing can lead to fatal toxicity. Always monitor blood counts, liver, and kidney function during treatment.
- Body Weight
- Below 5 kg
- Dose
- Not recommended
- Frequency
- Use only if prescribed
- Tracking Notes
- Dosing in infants must be determined strictly by a pediatric oncologist or rheumatologist using Body Surface Area (BSA).
- Body Weight
- 5-7 kg
- Dose
- BSA dependent
- Frequency
- Once weekly
- Tracking Notes
- Must be calculated using Body Surface Area (BSA) under specialist supervision.
- Body Weight
- 8-10 kg
- Dose
- BSA dependent
- Frequency
- Once weekly
- Tracking Notes
- Must be calculated using Body Surface Area (BSA) under specialist supervision.
- Body Weight
- 11-15 kg
- Dose
- BSA dependent
- Frequency
- Once weekly
- Tracking Notes
- Must be calculated using Body Surface Area (BSA) under specialist supervision.
- Body Weight
- 16-20 kg
- Dose
- BSA dependent
- Frequency
- Once weekly
- Tracking Notes
- Must be calculated using Body Surface Area (BSA) under specialist supervision.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not recommended | Use only if prescribed | Dosing in infants must be determined strictly by a pediatric oncologist or rheumatologist using Body Surface Area (BSA). |
| 5-7 kg | BSA dependent | Once weekly | Must be calculated using Body Surface Area (BSA) under specialist supervision. |
| 8-10 kg | BSA dependent | Once weekly | Must be calculated using Body Surface Area (BSA) under specialist supervision. |
| 11-15 kg | BSA dependent | Once weekly | Must be calculated using Body Surface Area (BSA) under specialist supervision. |
| 16-20 kg | BSA dependent | Once weekly | Must be calculated using Body Surface Area (BSA) under specialist supervision. |
Formulation
TabletInjection
Purpose
Used to treat severe rheumatoid arthritis, severe psoriasis, and certain types of cancers such as breast, lung, lymphatic, and osteosarcoma.
Generic Name
MethotrexateScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.