Azathioprine

A purine analogue that interferes with DNA synthesis, specifically suppressing T-cell activity. Often used to maintain remission in Crohn’s disease.

Dosage by Body Weight

Standard dose: 1.5–2.5 mg/kg daily. TPMT enzyme testing is recommended before starting to avoid toxicity.

  1. Body Weight
    20-30 kg
    Dose
    50 mg
    Frequency
    Once daily
    Tracking Notes
    Requires monthly blood counts to check for bone marrow suppression.

Formulation

Tablet

Purpose

Immunosuppressant for IBD, autoimmune hepatitis, and transplant rejection.

Generic Name

Azathioprine

Branded Drug Names

Azathioprine is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:

Scheduled Drug

Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.

Alternatives

Safety Advice

Alcohol

CAUTION

Azathioprine: Alcohol can increase liver strain, stomach irritation, or immune-related complications. Avoid alcohol unless your specialist allows it.

Pregnancy

CAUTION

Azathioprine: Use in pregnancy only under specialist advice because immune, cancer, or transplant treatment requires careful risk assessment.

Breast Feeding

CAUTION

Azathioprine: Breastfeeding may not be recommended with some immunosuppressive or chemotherapy medicines. Follow specialist advice.

Driving

CAUTION

Azathioprine: May cause dizziness, fatigue, nausea, or weakness. Avoid driving if affected.

Liver

CAUTION

Azathioprine: Can affect liver function and usually requires regular blood tests. Use only with specialist monitoring.

Kidney

CAUTION

Azathioprine: Kidney function may need close monitoring, particularly with calcineurin inhibitors or high-risk regimens.

Disclaimer: This information is for educational purposes only. WHO references and weight bands are simplified for tracking and must not replace medical advice. Always consult with a healthcare professional before starting or changing any medication.