Azathioprine
A purine analogue that interferes with DNA synthesis, specifically suppressing T-cell activity. Often used to maintain remission in Crohn’s disease.
Dosage by Body Weight
Standard dose: 1.5–2.5 mg/kg daily. TPMT enzyme testing is recommended before starting to avoid toxicity.
- Body Weight
- 20-30 kg
- Dose
- 50 mg
- Frequency
- Once daily
- Tracking Notes
- Requires monthly blood counts to check for bone marrow suppression.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| 20-30 kg | 50 mg | Once daily | Requires monthly blood counts to check for bone marrow suppression. |
Formulation
Purpose
Immunosuppressant for IBD, autoimmune hepatitis, and transplant rejection.
Generic Name
AzathioprineBranded Drug Names
Azathioprine is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.
Alternatives
Safety Advice
Alcohol
CAUTIONAzathioprine: Alcohol can increase liver strain, stomach irritation, or immune-related complications. Avoid alcohol unless your specialist allows it.
Pregnancy
CAUTIONAzathioprine: Use in pregnancy only under specialist advice because immune, cancer, or transplant treatment requires careful risk assessment.
Breast Feeding
CAUTIONAzathioprine: Breastfeeding may not be recommended with some immunosuppressive or chemotherapy medicines. Follow specialist advice.
Driving
CAUTIONAzathioprine: May cause dizziness, fatigue, nausea, or weakness. Avoid driving if affected.
Liver
CAUTIONAzathioprine: Can affect liver function and usually requires regular blood tests. Use only with specialist monitoring.
Kidney
CAUTIONAzathioprine: Kidney function may need close monitoring, particularly with calcineurin inhibitors or high-risk regimens.