Azoran
Azoran contains Azathioprine, an immunosuppressive antimetabolite. It works by inhibiting DNA and RNA synthesis, which curtails the proliferation of immune cells (specifically T and B lymphocytes) responsible for transplant rejection and autoimmune attacks on healthy body tissues.
Dosage by Body Weight
Azoran must be taken under strict medical supervision. The dosage is highly individualized and determined by body weight, clinical response, and hematological tolerance. It is typically taken once or twice daily, preferably after meals to reduce gastrointestinal side effects. Regular blood counts (CBC) are mandatory during therapy.
- Body Weight
- Below 5 kg
- Dose
- Highly restricted / Not routine
- Frequency
- Use only if prescribed by a specialist
- Tracking Notes
- Dosing in infants under 5 kg must be meticulously calculated by a pediatric specialist, usually starting at 1 mg/kg/day.
- Body Weight
- 5-7 kg
- Dose
- 5 mg to 15 mg daily
- Frequency
- Once daily or divided into two doses
- Tracking Notes
- Based on a standard starting dose of 1 to 2 mg/kg/day. Requires intensive monitoring of blood counts.
- Body Weight
- 8-10 kg
- Dose
- 8 mg to 25 mg daily
- Frequency
- Once daily or divided into two doses
- Tracking Notes
- Adjustments may be made depending on whether the indication is for transplantation or autoimmune disease.
- Body Weight
- 11-15 kg
- Dose
- 11 mg to 37.5 mg daily
- Frequency
- Once daily or divided into two doses
- Tracking Notes
- Monitor liver function tests (LFTs) and complete blood count (CBC) regularly.
- Body Weight
- 16-20 kg
- Dose
- 16 mg to 50 mg daily
- Frequency
- Once daily or divided into two doses
- Tracking Notes
- Maintenance doses may range up to 3 mg/kg/day depending on patient tolerance and clinical efficacy.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Highly restricted / Not routine | Use only if prescribed by a specialist | Dosing in infants under 5 kg must be meticulously calculated by a pediatric specialist, usually starting at 1 mg/kg/day. |
| 5-7 kg | 5 mg to 15 mg daily | Once daily or divided into two doses | Based on a standard starting dose of 1 to 2 mg/kg/day. Requires intensive monitoring of blood counts. |
| 8-10 kg | 8 mg to 25 mg daily | Once daily or divided into two doses | Adjustments may be made depending on whether the indication is for transplantation or autoimmune disease. |
| 11-15 kg | 11 mg to 37.5 mg daily | Once daily or divided into two doses | Monitor liver function tests (LFTs) and complete blood count (CBC) regularly. |
| 16-20 kg | 16 mg to 50 mg daily | Once daily or divided into two doses | Maintenance doses may range up to 3 mg/kg/day depending on patient tolerance and clinical efficacy. |
Formulation
Purpose
Prevention of organ transplant rejection (such as kidney, heart, and liver transplants) and treatment of severe autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus (SLE), Crohn's disease, and ulcerative colitis.
Generic Name
AzathioprineScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.