Dinoprostone
Dinoprostone is a synthetic preparation of the naturally occurring prostaglandin E2 (PGE2). It works by stimulating the myometrium of the pregnant uterus to contract, mimicking labor, and by acting on the cervix to cause softening, effacement, and dilation.
Dosage by Body Weight
Strictly administered by healthcare professionals in a hospital setting. Vaginal insert: 10 mg (releases ~0.3 mg/hr over 12 hours). Vaginal gel: 0.5 mg endocervically. Vaginal suppository: 20 mg repeated every 3 to 5 hours for pregnancy termination. Not indicated for pediatric use.
- Body Weight
- Below 5 kg
- Dose
- Not applicable
- Frequency
- Not applicable
- Tracking Notes
- Contraindicated. This medication is only indicated for adult obstetric patients.
- Body Weight
- 5-7 kg
- Dose
- Not applicable
- Frequency
- Not applicable
- Tracking Notes
- Contraindicated. This medication is only indicated for adult obstetric patients.
- Body Weight
- 8-10 kg
- Dose
- Not applicable
- Frequency
- Not applicable
- Tracking Notes
- Contraindicated. This medication is only indicated for adult obstetric patients.
- Body Weight
- 11-15 kg
- Dose
- Not applicable
- Frequency
- Not applicable
- Tracking Notes
- Contraindicated. This medication is only indicated for adult obstetric patients.
- Body Weight
- 16-20 kg
- Dose
- Not applicable
- Frequency
- Not applicable
- Tracking Notes
- Contraindicated. This medication is only indicated for adult obstetric patients.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not applicable | Not applicable | Contraindicated. This medication is only indicated for adult obstetric patients. |
| 5-7 kg | Not applicable | Not applicable | Contraindicated. This medication is only indicated for adult obstetric patients. |
| 8-10 kg | Not applicable | Not applicable | Contraindicated. This medication is only indicated for adult obstetric patients. |
| 11-15 kg | Not applicable | Not applicable | Contraindicated. This medication is only indicated for adult obstetric patients. |
| 16-20 kg | Not applicable | Not applicable | Contraindicated. This medication is only indicated for adult obstetric patients. |
Formulation
Purpose
Used for cervical ripening in pregnant women at or near term to facilitate labor induction. Also used for the termination of pregnancy and management of missed abortion or hydatidiform mole.
Generic Name
DinoprostoneBranded Drug Names
Dinoprostone is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.