Midazolam
Midazolam is a short-acting benzodiazepine central nervous system (CNS) depressant. It has sedative, amnestic, anxiolytic, muscle relaxant, and anticonvulsant properties. It is commonly administered intravenously for conscious sedation before diagnostic or therapeutic procedures, or via nasal/buccal routes for emergency rescue treatment of seizures.
Dosage by Body Weight
Dosage must be individualized. It is highly dependent on the patient's age, weight, clinical status, and the specific medical procedure or condition being treated. Administered only by healthcare professionals or trained caregivers in emergency seizure situations. Close monitoring of respiratory and cardiovascular function is required.
- Body Weight
- Below 5 kg
- Dose
- Not routinely recommended
- Frequency
- Use only under strict medical supervision
- Tracking Notes
- High risk of respiratory depression in neonates and small infants. Requires intensive care monitoring.
- Body Weight
- 5-7 kg
- Dose
- 2.5 mg (Buccal/Nasal) or 0.1-0.15 mg/kg (IV)
- Frequency
- Single dose for emergency seizure; do not repeat without medical instruction
- Tracking Notes
- Emergency rescue dose for seizures. Monitor breathing and sedation levels closely.
- Body Weight
- 8-10 kg
- Dose
- 2.5 mg to 5 mg (Buccal/Nasal) depending on age
- Frequency
- Single dose; may repeat once after 10 minutes if emergency services have not arrived
- Tracking Notes
- Often corresponding to infants aged 3 to 12 months. Watch for airway obstruction.
- Body Weight
- 11-15 kg
- Dose
- 5 mg (Buccal/Nasal)
- Frequency
- Single dose
- Tracking Notes
- Typical emergency rescue dose for toddlers (approx. 1 to 5 years) experiencing acute prolonged seizures.
- Body Weight
- 16-20 kg
- Dose
- 5 mg to 7.5 mg (Buccal/Nasal)
- Frequency
- Single dose
- Tracking Notes
- Dose adjustment based on age and clinical response. Seek immediate emergency medical care during use.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routinely recommended | Use only under strict medical supervision | High risk of respiratory depression in neonates and small infants. Requires intensive care monitoring. |
| 5-7 kg | 2.5 mg (Buccal/Nasal) or 0.1-0.15 mg/kg (IV) | Single dose for emergency seizure; do not repeat without medical instruction | Emergency rescue dose for seizures. Monitor breathing and sedation levels closely. |
| 8-10 kg | 2.5 mg to 5 mg (Buccal/Nasal) depending on age | Single dose; may repeat once after 10 minutes if emergency services have not arrived | Often corresponding to infants aged 3 to 12 months. Watch for airway obstruction. |
| 11-15 kg | 5 mg (Buccal/Nasal) | Single dose | Typical emergency rescue dose for toddlers (approx. 1 to 5 years) experiencing acute prolonged seizures. |
| 16-20 kg | 5 mg to 7.5 mg (Buccal/Nasal) | Single dose | Dose adjustment based on age and clinical response. Seek immediate emergency medical care during use. |
Formulation
Purpose
Used for preoperative sedation, anxiolysis, induction of anesthesia, and control of acute prolonged seizures (status epilepticus).
Generic Name
MidazolamBranded Drug Names
Midazolam is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.