Liposomal Amphotericin B
Liposomal Amphotericin B is a sterile, non-pyrogens lyophilized product for intravenous infusion. It consists of amphotericin B intercalated into a liposomal membrane, which significantly improves its safety profile, particularly reducing nephrotoxicity compared to conventional amphotericin B deoxycholate, while maintaining potent antifungal activity against a broad spectrum of fungal pathogens.
Dosage by Body Weight
Must be administered by intravenous infusion only. Do not administer as an intravenous bolus. Dilute only with 5% Dextrose Injection; do not mix with saline or other drugs. Typical adult and pediatric dosage ranges from 3 to 5 mg/kg/day depending on the severity and type of infection. Infuse over 60-120 minutes. Premedication with antipyretics, antihistamines, or antiemetics may be used to prevent infusion-related reactions.
- Body Weight
- Below 5 kg
- Dose
- 9 to 25 mg IV (calculated at 3-5 mg/kg)
- Frequency
- Once daily
- Tracking Notes
- Requires extreme caution and intensive monitoring of renal function and serum potassium levels in neonates.
- Body Weight
- 5-7 kg
- Dose
- 15 to 35 mg IV (calculated at 3-5 mg/kg)
- Frequency
- Once daily
- Tracking Notes
- Infuse over 120 minutes. Ensure adequate hydration prior to infusion to minimize nephrotoxicity.
- Body Weight
- 8-10 kg
- Dose
- 24 to 50 mg IV (calculated at 3-5 mg/kg)
- Frequency
- Once daily
- Tracking Notes
- Monitor serum creatinine, blood urea nitrogen (BUN), and electrolytes daily during initial therapy.
- Body Weight
- 11-15 kg
- Dose
- 33 to 75 mg IV (calculated at 3-5 mg/kg)
- Frequency
- Once daily
- Tracking Notes
- Dose may be adjusted up to 6 mg/kg/day for severe cryptococcal meningitis or refractory infections.
- Body Weight
- 16-20 kg
- Dose
- 48 to 100 mg IV (calculated at 3-5 mg/kg)
- Frequency
- Once daily
- Tracking Notes
- In-line filter (no less than 1.0 micron pore size) must be used during administration.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 9 to 25 mg IV (calculated at 3-5 mg/kg) | Once daily | Requires extreme caution and intensive monitoring of renal function and serum potassium levels in neonates. |
| 5-7 kg | 15 to 35 mg IV (calculated at 3-5 mg/kg) | Once daily | Infuse over 120 minutes. Ensure adequate hydration prior to infusion to minimize nephrotoxicity. |
| 8-10 kg | 24 to 50 mg IV (calculated at 3-5 mg/kg) | Once daily | Monitor serum creatinine, blood urea nitrogen (BUN), and electrolytes daily during initial therapy. |
| 11-15 kg | 33 to 75 mg IV (calculated at 3-5 mg/kg) | Once daily | Dose may be adjusted up to 6 mg/kg/day for severe cryptococcal meningitis or refractory infections. |
| 16-20 kg | 48 to 100 mg IV (calculated at 3-5 mg/kg) | Once daily | In-line filter (no less than 1.0 micron pore size) must be used during administration. |
Formulation
Purpose
Treatment of severe, systemic fungal infections including invasive aspergillosis, candidiasis, cryptococcal meningitis in HIV-infected patients, and visceral leishmaniasis.
Generic Name
Amphotericin B (Liposomal)Branded Drug Names
Liposomal Amphotericin B is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.