Lipo Ambi
Lipo Ambi contains Liposomal Amphotericin B, a lipid-associated formulation of the broad-spectrum antifungal drug Amphotericin B. The liposomal drug delivery system improves drug penetration and significantly reduces the risk of nephrotoxicity compared to conventional amphotericin B deoxycholate formulations.
Dosage by Body Weight
Must be administered only by intravenous infusion under clinical supervision. The dose must be calculated precisely based on body weight (typically 3 to 5 mg/kg/day depending on the severity and type of infection). Reconstitute only with sterile water and dilute only with 5% Dextrose injection; do not mix with saline solutions.
- Body Weight
- Below 5 kg
- Dose
- 12 mg - 25 mg (calculated as 3-5 mg/kg)
- Frequency
- Once daily by intravenous infusion
- Tracking Notes
- Administer with extreme caution. Requires strict clinical monitoring of renal, hepatic, and hematological parameters.
- Body Weight
- 5-7 kg
- Dose
- 15 mg - 35 mg (calculated as 3-5 mg/kg)
- Frequency
- Once daily by intravenous infusion
- Tracking Notes
- Infuse slowly over 120 minutes. Monitor closely for infusion-related reactions such as fever and chills.
- Body Weight
- 8-10 kg
- Dose
- 24 mg - 50 mg (calculated as 3-5 mg/kg)
- Frequency
- Once daily by intravenous infusion
- Tracking Notes
- Do not use an in-line membrane filter with a pore size less than 1.0 micron.
- Body Weight
- 11-15 kg
- Dose
- 33 mg - 75 mg (calculated as 3-5 mg/kg)
- Frequency
- Once daily by intravenous infusion
- Tracking Notes
- Regularly monitor serum potassium, magnesium, and creatinine levels during therapy.
- Body Weight
- 16-20 kg
- Dose
- 48 mg - 100 mg (calculated as 3-5 mg/kg)
- Frequency
- Once daily by intravenous infusion
- Tracking Notes
- Pre-medication with antihistamines or antipyretics may be considered to prevent infusion-related side effects.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 12 mg - 25 mg (calculated as 3-5 mg/kg) | Once daily by intravenous infusion | Administer with extreme caution. Requires strict clinical monitoring of renal, hepatic, and hematological parameters. |
| 5-7 kg | 15 mg - 35 mg (calculated as 3-5 mg/kg) | Once daily by intravenous infusion | Infuse slowly over 120 minutes. Monitor closely for infusion-related reactions such as fever and chills. |
| 8-10 kg | 24 mg - 50 mg (calculated as 3-5 mg/kg) | Once daily by intravenous infusion | Do not use an in-line membrane filter with a pore size less than 1.0 micron. |
| 11-15 kg | 33 mg - 75 mg (calculated as 3-5 mg/kg) | Once daily by intravenous infusion | Regularly monitor serum potassium, magnesium, and creatinine levels during therapy. |
| 16-20 kg | 48 mg - 100 mg (calculated as 3-5 mg/kg) | Once daily by intravenous infusion | Pre-medication with antihistamines or antipyretics may be considered to prevent infusion-related side effects. |
Formulation
Purpose
Treatment of severe, systemic fungal infections (such as invasive aspergillosis, cryptococcal meningitis, systemic candidiasis) and visceral leishmaniasis (kala-azar) in patients intolerant to conventional amphotericin B or with renal impairment.
Generic Name
Liposomal Amphotericin BScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.