Doxofylline
Doxofylline is a methylxanthine derivative with bronchodilator and anti-inflammatory activities. Unlike traditional xanthines like theophylline, it exhibits significantly lower affinity for adenosine receptors and does not interfere with calcium influx, resulting in fewer cardiac, central nervous system, and gastrointestinal side effects.
Dosage by Body Weight
Adults: Usually 400 mg once daily (preferably in the evening) or twice daily, as prescribed by a healthcare provider. Elderly patients may require a reduced dose. Pediatric dosage is calculated strictly by body weight.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy have not been established for very low birth weight infants.
- Body Weight
- 5-7 kg
- Dose
- 30 mg to 42 mg (approx. 1.5 mL to 2 mL of 100mg/5mL syrup)
- Frequency
- Twice daily
- Tracking Notes
- Calculated at approximately 6 mg/kg per dose. Administer with or after food.
- Body Weight
- 8-10 kg
- Dose
- 48 mg to 60 mg (approx. 2.4 mL to 3 mL of 100mg/5mL syrup)
- Frequency
- Twice daily
- Tracking Notes
- Monitor closely for any signs of hyper-excitability or gastric upset.
- Body Weight
- 11-15 kg
- Dose
- 66 mg to 90 mg (approx. 3.3 mL to 4.5 mL of 100mg/5mL syrup)
- Frequency
- Twice daily
- Tracking Notes
- Ensure exact dosing using a graduated syringe or measuring cup.
- Body Weight
- 16-20 kg
- Dose
- 96 mg to 120 mg (approx. 4.8 mL to 6 mL of 100mg/5mL syrup)
- Frequency
- Twice daily
- Tracking Notes
- Can transition to equivalent solid oral dosage forms if the child can safely swallow tablets.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Safety and efficacy have not been established for very low birth weight infants. |
| 5-7 kg | 30 mg to 42 mg (approx. 1.5 mL to 2 mL of 100mg/5mL syrup) | Twice daily | Calculated at approximately 6 mg/kg per dose. Administer with or after food. |
| 8-10 kg | 48 mg to 60 mg (approx. 2.4 mL to 3 mL of 100mg/5mL syrup) | Twice daily | Monitor closely for any signs of hyper-excitability or gastric upset. |
| 11-15 kg | 66 mg to 90 mg (approx. 3.3 mL to 4.5 mL of 100mg/5mL syrup) | Twice daily | Ensure exact dosing using a graduated syringe or measuring cup. |
| 16-20 kg | 96 mg to 120 mg (approx. 4.8 mL to 6 mL of 100mg/5mL syrup) | Twice daily | Can transition to equivalent solid oral dosage forms if the child can safely swallow tablets. |
Formulation
Purpose
Used for the treatment and maintenance of chronic obstructive pulmonary disease (COPD), asthma, and bronchospasm.
Generic Name
DoxofyllineBranded Drug Names
Doxofylline is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.