Pyrazinamide Generic
Pyrazinamide is a bacteriostatic or bactericidal antituberculosis agent that is active against Mycobacterium tuberculosis. It is a prodrug converted into its active form, pyrazinoic acid, within the mycobacterium. It is particularly active in acidic intracellular environments, making it highly effective at sterilizing slow-growing intracellular bacilli.
Dosage by Body Weight
Pyrazinamide must always be used in combination with other anti-TB medications. It is taken once daily or as part of a supervised intermittent regimen (DOTS). Dose adjustments are necessary based on patient body weight and renal/hepatic function.
- Body Weight
- Below 5 kg
- Dose
- Not routine / Calculated by precise body weight
- Frequency
- Once daily
- Tracking Notes
- Consult a pediatric specialist. Requires highly individualized dosing, typically calculated at 30-40 mg/kg daily.
- Body Weight
- 5-7 kg
- Dose
- 150 mg to 250 mg
- Frequency
- Once daily
- Tracking Notes
- Administer with standard pediatric liquid vehicle or crush tablets as advised by a pharmacist.
- Body Weight
- 8-10 kg
- Dose
- 250 mg to 350 mg
- Frequency
- Once daily
- Tracking Notes
- Dosing targeted to achieve approximately 35 mg/kg daily. Monitor liver function regularly.
- Body Weight
- 11-15 kg
- Dose
- 400 mg to 500 mg
- Frequency
- Once daily
- Tracking Notes
- Dosing may utilize a combination of standard strength tablets (e.g., 500 mg).
- Body Weight
- 16-20 kg
- Dose
- 500 mg to 700 mg
- Frequency
- Once daily
- Tracking Notes
- Ensure patient maintains adequate hydration throughout treatment to prevent hyperuricemia.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine / Calculated by precise body weight | Once daily | Consult a pediatric specialist. Requires highly individualized dosing, typically calculated at 30-40 mg/kg daily. |
| 5-7 kg | 150 mg to 250 mg | Once daily | Administer with standard pediatric liquid vehicle or crush tablets as advised by a pharmacist. |
| 8-10 kg | 250 mg to 350 mg | Once daily | Dosing targeted to achieve approximately 35 mg/kg daily. Monitor liver function regularly. |
| 11-15 kg | 400 mg to 500 mg | Once daily | Dosing may utilize a combination of standard strength tablets (e.g., 500 mg). |
| 16-20 kg | 500 mg to 700 mg | Once daily | Ensure patient maintains adequate hydration throughout treatment to prevent hyperuricemia. |
Formulation
Purpose
Used in combination with other anti-tuberculosis drugs for the initial phase of treating active tuberculosis (TB).
Generic Name
PyrazinamideBranded Drug Names
Pyrazinamide Generic is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.