Zinamide
Zinamide contains Pyrazinamide, which is an antibacterial agent active against Mycobacterium tuberculosis. It is primarily used during the initial phase of short-course tuberculosis treatment to help kill bacteria residing within acidic intracellular environments, preventing relapse and helping to shorten the overall treatment duration.
Dosage by Body Weight
The standard pediatric dosage is typically 30-40 mg/kg body weight once daily, or 50-70 mg/kg three times a week. It must be taken in combination with other anti-TB drugs as prescribed by a healthcare provider. Liver function tests and serum uric acid levels should be monitored regularly during treatment.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Requires strict specialist pediatric assessment and monitoring.
- Body Weight
- 5-7 kg
- Dose
- 150 mg to 250 mg
- Frequency
- Once daily
- Tracking Notes
- May require dividing dispersible tablets or utilizing specialized pediatric formulations.
- Body Weight
- 8-10 kg
- Dose
- 250 mg to 350 mg
- Frequency
- Once daily
- Tracking Notes
- Dose must be precisely calculated based on the standard 30-40 mg/kg guideline.
- Body Weight
- 11-15 kg
- Dose
- 350 mg to 500 mg
- Frequency
- Once daily
- Tracking Notes
- Do not exceed the daily dose calculated by the prescribing clinician.
- Body Weight
- 16-20 kg
- Dose
- 500 mg to 700 mg
- Frequency
- Once daily
- Tracking Notes
- Usually equivalent to one 500mg tablet. Always take alongside other prescribed tuberculosis medications.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Requires strict specialist pediatric assessment and monitoring. |
| 5-7 kg | 150 mg to 250 mg | Once daily | May require dividing dispersible tablets or utilizing specialized pediatric formulations. |
| 8-10 kg | 250 mg to 350 mg | Once daily | Dose must be precisely calculated based on the standard 30-40 mg/kg guideline. |
| 11-15 kg | 350 mg to 500 mg | Once daily | Do not exceed the daily dose calculated by the prescribing clinician. |
| 16-20 kg | 500 mg to 700 mg | Once daily | Usually equivalent to one 500mg tablet. Always take alongside other prescribed tuberculosis medications. |
Formulation
Purpose
Zinamide is an antitubercular medication used in combination with other drugs to treat active tuberculosis (TB) infections.
Generic Name
PyrazinamideScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.