Pyzina
Pyzina contains Pyrazinamide, an antibacterial prescription medication specifically indicated for the treatment of tuberculosis. It is an essential component of short-course combination therapy, typically used during the initial intensive phase of TB treatment to kill slowly replicating bacteria within macrophages.
Dosage by Body Weight
Must be taken exactly as prescribed by a doctor, usually once daily with or without food. It must always be used in combination with other anti-TB medications to prevent drug resistance. Regular liver function and uric acid tests are recommended during treatment.
- Body Weight
- Below 5 kg
- Dose
- Requires specialist calculation (typically 30 mg/kg)
- Frequency
- Once daily
- Tracking Notes
- Not routinely administered without strict specialist supervision. Safety in neonates requires careful monitoring.
- Body Weight
- 5-7 kg
- Dose
- 150 mg
- Frequency
- Once daily
- Tracking Notes
- Often administered using child-friendly dispersible formulations as part of combined TB regimens.
- Body Weight
- 8-10 kg
- Dose
- 300 mg
- Frequency
- Once daily
- Tracking Notes
- Adjust dose strictly under pediatric guidance. Monitor for signs of hepatotoxicity.
- Body Weight
- 11-15 kg
- Dose
- 450 mg
- Frequency
- Once daily
- Tracking Notes
- Can be given as crushed or dispersible tablets. Ensure adequate hydration.
- Body Weight
- 16-20 kg
- Dose
- 600 mg
- Frequency
- Once daily
- Tracking Notes
- Dose can be adjusted based on clinical response and tolerance under medical supervision.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Requires specialist calculation (typically 30 mg/kg) | Once daily | Not routinely administered without strict specialist supervision. Safety in neonates requires careful monitoring. |
| 5-7 kg | 150 mg | Once daily | Often administered using child-friendly dispersible formulations as part of combined TB regimens. |
| 8-10 kg | 300 mg | Once daily | Adjust dose strictly under pediatric guidance. Monitor for signs of hepatotoxicity. |
| 11-15 kg | 450 mg | Once daily | Can be given as crushed or dispersible tablets. Ensure adequate hydration. |
| 16-20 kg | 600 mg | Once daily | Dose can be adjusted based on clinical response and tolerance under medical supervision. |
Formulation
Purpose
Used in combination with other antitubercular drugs for the treatment of active tuberculosis (TB).
Generic Name
PyrazinamideScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.