Pyrazinamide

A key component of short-course TB therapy. It is specifically active against bacteria residing in acidic environments like macrophages.

Dosage by Body Weight

Pediatric dose: 30-40 mg/kg once daily for the first 2 months of TB treatment.

Weight-based dosage tracking table for Pyrazinamide, including body weight, dose, frequency, and tracking notes.
Body Weight	Dose	Frequency	Tracking Notes
5-7 kg	250 mg	Once daily	Monitor liver function tests and uric acid levels.
8-12 kg	400 mg	Once daily	May cause joint pain (arthralgia).
13-18 kg	600 mg	Once daily	Usually given as part of a Fixed Dose Combination (FDC).

Tablet

Anti-tuberculosis medication used in the initial phase of treatment.

Pyrazinamide is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:

Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.

CAUTION

Pyrazinamide: Alcohol may worsen dehydration, stomach upset, or interfere with nutritional recovery. Avoid or limit alcohol.

SAFE IF PRESCRIBED

Pyrazinamide: Generally safe in pregnancy when used at recommended doses or as prescribed. Avoid excessive supplementation.

SAFE

Pyrazinamide: Generally compatible with breastfeeding when used at recommended doses. Ask a healthcare provider before high-dose use.

SAFE

Pyrazinamide: Usually does not affect driving. Avoid driving only if you feel unwell, dizzy, or weak from the underlying condition.

SAFE IF PRESCRIBED

Pyrazinamide: Usually safe at recommended doses, but high-dose or fat-soluble vitamin use should be medically supervised in liver disease.

CAUTION

Pyrazinamide: Kidney disease may require avoiding or adjusting minerals and electrolytes such as potassium, magnesium, calcium, or phosphate.