Pyrazide
Pyrazide is an antimycobacterial medicine containing Pyrazinamide. It is specifically active against intracellular Mycobacterium tuberculosis during the early, active phase of treatment. It is highly effective in acidic environments, such as inside inflammatory cells, and is always used in combination with other anti-TB agents to prevent drug resistance.
Dosage by Body Weight
Pyrazide must be taken exactly as prescribed by a physician, usually once daily. Dosage is determined strictly by patient body weight. Regular monitoring of liver function and serum uric acid levels is highly recommended during therapy.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy in low-birth-weight infants or very small children should be managed strictly by a specialist.
- Body Weight
- 5-7 kg
- Dose
- 125 mg to 150 mg
- Frequency
- Once daily
- Tracking Notes
- Calculated at approximately 20-30 mg/kg daily. Tablet splitting or liquid dispersing may be required.
- Body Weight
- 8-10 kg
- Dose
- 200 mg to 250 mg
- Frequency
- Once daily
- Tracking Notes
- Usually equivalent to half of a standard 500 mg tablet.
- Body Weight
- 11-15 kg
- Dose
- 250 mg to 375 mg
- Frequency
- Once daily
- Tracking Notes
- Adjust dosage carefully to prevent hepatic toxicity.
- Body Weight
- 16-20 kg
- Dose
- 375 mg to 500 mg
- Frequency
- Once daily
- Tracking Notes
- Equivalent to 3/4 to 1 full 500 mg tablet daily.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Safety and efficacy in low-birth-weight infants or very small children should be managed strictly by a specialist. |
| 5-7 kg | 125 mg to 150 mg | Once daily | Calculated at approximately 20-30 mg/kg daily. Tablet splitting or liquid dispersing may be required. |
| 8-10 kg | 200 mg to 250 mg | Once daily | Usually equivalent to half of a standard 500 mg tablet. |
| 11-15 kg | 250 mg to 375 mg | Once daily | Adjust dosage carefully to prevent hepatic toxicity. |
| 16-20 kg | 375 mg to 500 mg | Once daily | Equivalent to 3/4 to 1 full 500 mg tablet daily. |
Formulation
Purpose
Used in combination with other antitubercular drugs for the initial treatment of active tuberculosis (TB).
Generic Name
PyrazinamideScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.