Isokin
Isokin contains Isoniazid, an antibacterial medication that belongs to the class of antitubercular drugs. It works by preventing the growth of the bacteria that cause tuberculosis, specifically by disrupting the bacterial cell wall synthesis. It is usually prescribed in combination with other anti-TB medications to treat active disease and as monotherapy for latent tuberculosis prevention. Pyridoxine (Vitamin B6) is often recommended concurrently to prevent peripheral neuropathy.
Dosage by Body Weight
Must be taken exactly as prescribed by a doctor, usually once daily on an empty stomach (1 hour before or 2 hours after meals) to ensure optimal absorption. Do not skip doses or stop therapy early, as this can lead to drug-resistant strains of tuberculosis.
- Body Weight
- Below 5 kg
- Dose
- Not routine / 30 mg to 50 mg
- Frequency
- Once daily as prescribed
- Tracking Notes
- Dosage must be calculated and monitored closely by a pediatrician or TB specialist.
- Body Weight
- 5-7 kg
- Dose
- 50 mg to 70 mg (approx. 2.5 mL to 3.5 mL of 100mg/5mL syrup)
- Frequency
- Once daily
- Tracking Notes
- Take on an empty stomach. Pyridoxine supplementation may be advised.
- Body Weight
- 8-10 kg
- Dose
- 80 mg to 100 mg (approx. 4 mL to 5 mL of 100mg/5mL syrup)
- Frequency
- Once daily
- Tracking Notes
- Ensure patient completes the full course to prevent resistance.
- Body Weight
- 11-15 kg
- Dose
- 110 mg to 150 mg (approx. 5.5 mL to 7.5 mL of 100mg/5mL syrup)
- Frequency
- Once daily
- Tracking Notes
- Regular monitoring of liver function is recommended during prolonged use.
- Body Weight
- 16-20 kg
- Dose
- 160 mg to 200 mg (approx. 8 mL to 10 mL of 100mg/5mL syrup)
- Frequency
- Once daily
- Tracking Notes
- May transition to appropriate tablet strength under physician guidance.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine / 30 mg to 50 mg | Once daily as prescribed | Dosage must be calculated and monitored closely by a pediatrician or TB specialist. |
| 5-7 kg | 50 mg to 70 mg (approx. 2.5 mL to 3.5 mL of 100mg/5mL syrup) | Once daily | Take on an empty stomach. Pyridoxine supplementation may be advised. |
| 8-10 kg | 80 mg to 100 mg (approx. 4 mL to 5 mL of 100mg/5mL syrup) | Once daily | Ensure patient completes the full course to prevent resistance. |
| 11-15 kg | 110 mg to 150 mg (approx. 5.5 mL to 7.5 mL of 100mg/5mL syrup) | Once daily | Regular monitoring of liver function is recommended during prolonged use. |
| 16-20 kg | 160 mg to 200 mg (approx. 8 mL to 10 mL of 100mg/5mL syrup) | Once daily | May transition to appropriate tablet strength under physician guidance. |