Rimifon
Rimifon (Isoniazid) is a primary bactericidal antimycobacterial drug used as a cornerstone of tuberculosis therapy. It selectively inhibits the synthesis of mycolic acids, which are essential components of the mycobacterial cell wall. It is highly effective against actively replicating Mycobacterium tuberculosis.
Dosage by Body Weight
Dosage must be customized based on whether it is used for treatment or prophylaxis, and is typically calculated by body weight. For active TB, it is always used in combination with other drugs to prevent resistance. Pyridoxine (Vitamin B6) supplementation is often recommended alongside Rimifon to prevent peripheral neuropathy, especially in nutritional deficiency, pregnancy, or diabetes.
- Body Weight
- Below 5 kg
- Dose
- 10-15 mg/kg
- Frequency
- Once daily
- Tracking Notes
- Requires strict clinical supervision. Liquid formulations or extemporaneously compounded suspensions should be used for accurate dosing.
- Body Weight
- 5-7 kg
- Dose
- 50 mg to 105 mg
- Frequency
- Once daily
- Tracking Notes
- Monitor hepatic function closely. Administer on an empty stomach (1 hour before or 2 hours after meals).
- Body Weight
- 8-10 kg
- Dose
- 80 mg to 150 mg
- Frequency
- Once daily
- Tracking Notes
- Concomitant administration of Pyridoxine (Vitamin B6) is highly recommended in pediatric patients.
- Body Weight
- 11-15 kg
- Dose
- 110 mg to 225 mg
- Frequency
- Once daily
- Tracking Notes
- Adjust dose according to the specific treatment regimen (daily vs. intermittent therapy under DOTS).
- Body Weight
- 16-20 kg
- Dose
- 160 mg to 300 mg
- Frequency
- Once daily
- Tracking Notes
- Do not exceed the maximum daily adult dosage of 300 mg unless specifically directed by a tuberculosis specialist.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 10-15 mg/kg | Once daily | Requires strict clinical supervision. Liquid formulations or extemporaneously compounded suspensions should be used for accurate dosing. |
| 5-7 kg | 50 mg to 105 mg | Once daily | Monitor hepatic function closely. Administer on an empty stomach (1 hour before or 2 hours after meals). |
| 8-10 kg | 80 mg to 150 mg | Once daily | Concomitant administration of Pyridoxine (Vitamin B6) is highly recommended in pediatric patients. |
| 11-15 kg | 110 mg to 225 mg | Once daily | Adjust dose according to the specific treatment regimen (daily vs. intermittent therapy under DOTS). |
| 16-20 kg | 160 mg to 300 mg | Once daily | Do not exceed the maximum daily adult dosage of 300 mg unless specifically directed by a tuberculosis specialist. |
Formulation
Purpose
Used for the treatment of active tuberculosis (TB) infections in combination with other antituberculosis medications, and for the prophylaxis (prevention) of tuberculosis in high-risk individuals.
Generic Name
IsoniazidScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.