Nydrazid
Nydrazid is a brand name of isoniazid, an antibacterial drug used as a first-line agent for the treatment of active tuberculosis (in combination with other antituberculosis drugs) and for the prophylaxis of latent tuberculosis. It works by inhibiting the synthesis of mycolic acids, which are essential components of the mycobacterial cell wall.
Dosage by Body Weight
Standard adult daily dose is 5 mg/kg (up to 300 mg) daily in a single dose. Standard pediatric daily dose is 10 to 15 mg/kg (up to 300 mg) daily in a single dose. Often co-prescribed with pyridoxine (Vitamin B6) to prevent peripheral neuropathy, especially in patients at risk of deficiency.
- Body Weight
- Below 5 kg
- Dose
- 30 mg to 50 mg
- Frequency
- Once daily
- Tracking Notes
- Consult a pediatric specialist; pyridoxine (Vitamin B6) supplementation is highly recommended.
- Body Weight
- 5-7 kg
- Dose
- 50 mg to 100 mg
- Frequency
- Once daily
- Tracking Notes
- Based on pediatric guideline dose of 10-15 mg/kg/day. Monitor hepatic function.
- Body Weight
- 8-10 kg
- Dose
- 80 mg to 150 mg
- Frequency
- Once daily
- Tracking Notes
- Can be administered using oral liquid formulations or crushed tablets.
- Body Weight
- 11-15 kg
- Dose
- 110 mg to 225 mg
- Frequency
- Once daily
- Tracking Notes
- Ensure regular follow-up for liver enzyme monitoring.
- Body Weight
- 16-20 kg
- Dose
- 160 mg to 300 mg
- Frequency
- Once daily
- Tracking Notes
- Do not exceed the maximum standard pediatric dose of 300 mg per day.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 30 mg to 50 mg | Once daily | Consult a pediatric specialist; pyridoxine (Vitamin B6) supplementation is highly recommended. |
| 5-7 kg | 50 mg to 100 mg | Once daily | Based on pediatric guideline dose of 10-15 mg/kg/day. Monitor hepatic function. |
| 8-10 kg | 80 mg to 150 mg | Once daily | Can be administered using oral liquid formulations or crushed tablets. |
| 11-15 kg | 110 mg to 225 mg | Once daily | Ensure regular follow-up for liver enzyme monitoring. |
| 16-20 kg | 160 mg to 300 mg | Once daily | Do not exceed the maximum standard pediatric dose of 300 mg per day. |
Formulation
Purpose
Treatment and prevention of active and latent tuberculosis (TB) caused by Mycobacterium tuberculosis.
Generic Name
IsoniazidScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.