Laniazid
Laniazid is a brand name for isoniazid, a primary first-line antituberculosis medication. It works by inhibiting the synthesis of mycolic acids, which are essential components of the Mycobacterium tuberculosis cell wall, thereby killing active bacteria and preventing further bacterial growth.
Dosage by Body Weight
Take on an empty stomach at least 1 hour before or 2 hours after meals to ensure maximum absorption. Concomitant administration of Pyridoxine (Vitamin B6) at 10-50 mg daily is recommended for patients at risk of neuropathy (including children, pregnant women, and malnourished patients). Always complete the full course of treatment as prescribed.
- Body Weight
- Below 5 kg
- Dose
- 10 mg/kg to 15 mg/kg per day
- Frequency
- Once daily
- Tracking Notes
- Requires precise measurement using a pediatric oral syringe. Consult a pediatric specialist.
- Body Weight
- 5-7 kg
- Dose
- 50 mg to 75 mg
- Frequency
- Once daily
- Tracking Notes
- Oral liquid formulation is preferred for precise dosing in infants.
- Body Weight
- 8-10 kg
- Dose
- 80 mg to 100 mg
- Frequency
- Once daily
- Tracking Notes
- Ensure daily intake of supplemental Vitamin B6 (pyridoxine) to prevent peripheral neuropathy.
- Body Weight
- 11-15 kg
- Dose
- 110 mg to 150 mg
- Frequency
- Once daily
- Tracking Notes
- Regular monitoring of hepatic transaminases (liver enzymes) is recommended.
- Body Weight
- 16-20 kg
- Dose
- 160 mg to 200 mg
- Frequency
- Once daily
- Tracking Notes
- Do not exceed the maximum daily adult dose of 300 mg.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 10 mg/kg to 15 mg/kg per day | Once daily | Requires precise measurement using a pediatric oral syringe. Consult a pediatric specialist. |
| 5-7 kg | 50 mg to 75 mg | Once daily | Oral liquid formulation is preferred for precise dosing in infants. |
| 8-10 kg | 80 mg to 100 mg | Once daily | Ensure daily intake of supplemental Vitamin B6 (pyridoxine) to prevent peripheral neuropathy. |
| 11-15 kg | 110 mg to 150 mg | Once daily | Regular monitoring of hepatic transaminases (liver enzymes) is recommended. |
| 16-20 kg | 160 mg to 200 mg | Once daily | Do not exceed the maximum daily adult dose of 300 mg. |
Formulation
Purpose
Treatment of active tuberculosis (in combination with other antituberculosis agents) and prophylaxis (preventative therapy) of latent tuberculosis infection.
Generic Name
IsoniazidScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.