Rifamate
Rifamate is a combination prescription antibiotic containing rifampin and isoniazid. It is indicated for the treatment of active tuberculosis (TB). Rifampin acts by inhibiting bacterial RNA synthesis, while isoniazid inhibits the synthesis of mycolic acids, disrupting the bacterial cell wall. Combining these two drugs in one capsule helps improve compliance and reduces the risk of drug-resistant TB strains developing.
Dosage by Body Weight
The standard adult dosage is 2 capsules taken orally once daily, either 1 hour before or 2 hours after a meal. Rifamate is not recommended for patients weighing less than 45 kg (100 lbs) or pediatric patients because the fixed-dose combination does not allow for individual dose adjustments.
- Body Weight
- Below 5 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Fixed-dose combination cannot be adjusted for infants. Use individual single-drug components to calculate appropriate pediatric doses.
- Body Weight
- 5-7 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Use individual single-drug components instead of the combination capsule.
- Body Weight
- 8-10 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Use individual single-drug components instead of the combination capsule.
- Body Weight
- 11-15 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Use individual single-drug components instead of the combination capsule.
- Body Weight
- 16-20 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Use individual single-drug components instead of the combination capsule.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not recommended | N/A | Fixed-dose combination cannot be adjusted for infants. Use individual single-drug components to calculate appropriate pediatric doses. |
| 5-7 kg | Not recommended | N/A | Use individual single-drug components instead of the combination capsule. |
| 8-10 kg | Not recommended | N/A | Use individual single-drug components instead of the combination capsule. |
| 11-15 kg | Not recommended | N/A | Use individual single-drug components instead of the combination capsule. |
| 16-20 kg | Not recommended | N/A | Use individual single-drug components instead of the combination capsule. |
Formulation
Purpose
Treatment of pulmonary tuberculosis in patients where the combination of rifampin and isoniazid is appropriate.
Generic Name
Rifampin and IsoniazidScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.