Sirolimus
Sirolimus is an immunosuppressive agent that inhibits T-lymphocyte activation and proliferation. It is primarily used to prevent renal transplant rejection, often in combination with other immunosuppressive drugs, and to treat lymphangioleiomyomatosis, a rare progressive lung disease.
Dosage by Body Weight
Dosage must be highly individualized and managed by a specialist. Standard adult dosing starts with a loading dose of 6 mg followed by 2 mg daily, adjusted based on therapeutic drug monitoring (target blood trough concentrations). Pediatric dosing in children 13 years of age or older (weighing less than 40 kg) is calculated based on body surface area (1 mg/m² daily after a 3 mg/m² loading dose).
- Body Weight
- Below 5 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Safety and efficacy have not been established in this weight range. Highly specialized setting only.
- Body Weight
- 5-7 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Safety and efficacy are not established. Pediatric transplant specialist supervision required.
- Body Weight
- 8-10 kg
- Dose
- Specialist calculation
- Frequency
- Once daily
- Tracking Notes
- Must be calculated by a specialist using Body Surface Area (BSA) and monitored closely via blood trough levels.
- Body Weight
- 11-15 kg
- Dose
- Specialist calculation
- Frequency
- Once daily
- Tracking Notes
- Typically based on 1 mg/m² daily maintenance after a 3 mg/m² loading dose, adjusted to target therapeutic range.
- Body Weight
- 16-20 kg
- Dose
- Specialist calculation
- Frequency
- Once daily
- Tracking Notes
- Dosed based on Body Surface Area (BSA) under strict specialist guidance. Blood concentration monitoring is mandatory.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not recommended | N/A | Safety and efficacy have not been established in this weight range. Highly specialized setting only. |
| 5-7 kg | Not recommended | N/A | Safety and efficacy are not established. Pediatric transplant specialist supervision required. |
| 8-10 kg | Specialist calculation | Once daily | Must be calculated by a specialist using Body Surface Area (BSA) and monitored closely via blood trough levels. |
| 11-15 kg | Specialist calculation | Once daily | Typically based on 1 mg/m² daily maintenance after a 3 mg/m² loading dose, adjusted to target therapeutic range. |
| 16-20 kg | Specialist calculation | Once daily | Dosed based on Body Surface Area (BSA) under strict specialist guidance. Blood concentration monitoring is mandatory. |
Formulation
Purpose
To prevent organ rejection in renal transplant recipients and to treat lymphangioleiomyomatosis (LAM).
Generic Name
SirolimusBranded Drug Names
Sirolimus is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.