Rifampicin

A bactericidal antibiotic that inhibits bacterial RNA polymerase. It is a cornerstone of the multi-drug regimen used to treat TB.

Dosage by Body Weight

Standard pediatric dose: 15 mg/kg (range 10-20 mg/kg) once daily. Should be taken on an empty stomach 1 hour before or 2 hours after meals.

  1. Body Weight
    5-7 kg
    Dose
    75 mg to 100 mg
    Frequency
    Once daily
    Tracking Notes
    May turn urine, sweat, and tears a harmless orange-red color.
  2. Body Weight
    8-12 kg
    Dose
    150 mg
    Frequency
    Once daily
    Tracking Notes
    Monitor liver function tests throughout treatment.
  3. Body Weight
    13-18 kg
    Dose
    225 mg to 300 mg
    Frequency
    Once daily
    Tracking Notes
    Avoid wearing soft contact lenses as they may become permanently stained.

Formulation

CapsuleSyrupSuspension

Purpose

A core antibiotic for the treatment of Tuberculosis (TB) and leprosy.

Generic Name

Rifampin

Branded Drug Names

Rifampicin is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:

Scheduled Drug

Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.

Alternatives

Safety Advice

Alcohol

CAUTION

Rifampicin: Alcohol may worsen infection-related dehydration, dizziness, or stomach upset. Avoid or limit alcohol during antibiotic treatment.

Pregnancy

SAFE IF PRESCRIBED

Rifampicin: Use during pregnancy only when prescribed for a bacterial infection; the prescriber will choose the safest suitable antibiotic.

Breast Feeding

SAFE IF PRESCRIBED

Rifampicin: Many antibiotics are compatible with breastfeeding when prescribed, but monitor the infant for diarrhea, rash, or thrush.

Driving

SAFE

Rifampicin: Usually does not affect driving, but dizziness, weakness, or illness symptoms can occur. Avoid driving if affected.

Liver

CAUTION

Rifampicin: Use caution in liver disease or if jaundice, dark urine, or severe fatigue occurs during treatment.

Kidney

CAUTION

Rifampicin: Some antibiotics require dose adjustment or monitoring in kidney disease. Use exactly as prescribed.

Disclaimer: This information is for educational purposes only. WHO references and weight bands are simplified for tracking and must not replace medical advice. Always consult with a healthcare professional before starting or changing any medication.