R-Cinex
R-Cinex is a combination prescription medicine containing Rifampicin and Isoniazid. It is used in the treatment and prevention of tuberculosis. Rifampicin is a rifamycin-type antibiotic that blocks bacterial RNA synthesis, while Isoniazid is an antibacterial agent that interferes with bacterial cell wall synthesis. Complete adherence to the treatment regimen is crucial to prevent drug resistance.
Dosage by Body Weight
Must be taken on an empty stomach, either 1 hour before or 2 hours after meals, as food significantly decreases the absorption of both active ingredients. It is typically administered once daily in the morning.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Requires strict specialist supervision and precise dosing using liquid suspensions.
- Body Weight
- 5-7 kg
- Dose
- Rifampicin 50-70 mg + Isoniazid 25-35 mg
- Frequency
- Once daily
- Tracking Notes
- Dosed using specialized pediatric dispersible tablets or suspension.
- Body Weight
- 8-10 kg
- Dose
- Rifampicin 80-100 mg + Isoniazid 40-50 mg
- Frequency
- Once daily
- Tracking Notes
- Monitor hepatic function closely in pediatric patients.
- Body Weight
- 11-15 kg
- Dose
- Rifampicin 150 mg + Isoniazid 75 mg
- Frequency
- Once daily
- Tracking Notes
- Commonly corresponds to 1 tablet of R-Cinex Kid formulation.
- Body Weight
- 16-20 kg
- Dose
- Rifampicin 200-225 mg + Isoniazid 100-112.5 mg
- Frequency
- Once daily
- Tracking Notes
- Dose must be adjusted dynamically based on clinical progress and weight changes.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Requires strict specialist supervision and precise dosing using liquid suspensions. |
| 5-7 kg | Rifampicin 50-70 mg + Isoniazid 25-35 mg | Once daily | Dosed using specialized pediatric dispersible tablets or suspension. |
| 8-10 kg | Rifampicin 80-100 mg + Isoniazid 40-50 mg | Once daily | Monitor hepatic function closely in pediatric patients. |
| 11-15 kg | Rifampicin 150 mg + Isoniazid 75 mg | Once daily | Commonly corresponds to 1 tablet of R-Cinex Kid formulation. |
| 16-20 kg | Rifampicin 200-225 mg + Isoniazid 100-112.5 mg | Once daily | Dose must be adjusted dynamically based on clinical progress and weight changes. |
Formulation
Purpose
Treatment of active pulmonary and extra-pulmonary Tuberculosis (TB) infections.
Generic Name
Rifampicin + IsoniazidScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.