Propofol
Propofol is a short-acting, intravenously administered general anesthetic and sedative. It works by slowing the activity of the brain and nervous system. It is characterized by a rapid onset of action and a quick recovery time compared to other sedatives. It is strictly for clinical use and must be administered only by trained anesthesia providers or intensive care specialists.
Dosage by Body Weight
Dosage must be strictly individualized based on the patient's age, body weight, physical status, and the specific clinical procedure. It is administered intravenously as an injection or continuous infusion. Continuous monitoring of respiratory and cardiovascular functions is mandatory.
- Body Weight
- Below 5 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Safety and efficacy have not been established in neonates and infants under 2 months of age.
- Body Weight
- 5-7 kg
- Dose
- 2.5 to 3.5 mg/kg (induction)
- Frequency
- Single slow intravenous injection
- Tracking Notes
- Administered strictly by a qualified healthcare professional. Titrate to clinical response.
- Body Weight
- 8-10 kg
- Dose
- 2.5 to 3.5 mg/kg (induction)
- Frequency
- Single slow intravenous injection
- Tracking Notes
- Pediatric patients often require higher doses per kg compared to adults. Monitor oxygenation constantly.
- Body Weight
- 11-15 kg
- Dose
- 2.5 to 3.5 mg/kg (induction)
- Frequency
- Single slow intravenous injection
- Tracking Notes
- Lower doses may be required for pediatric patients with compromised cardiorespiratory status.
- Body Weight
- 16-20 kg
- Dose
- 2.5 to 3.5 mg/kg (induction)
- Frequency
- Single slow intravenous injection
- Tracking Notes
- Maintenance of anesthesia is typically achieved with a continuous infusion of 125 to 300 mcg/kg/min.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not recommended | N/A | Safety and efficacy have not been established in neonates and infants under 2 months of age. |
| 5-7 kg | 2.5 to 3.5 mg/kg (induction) | Single slow intravenous injection | Administered strictly by a qualified healthcare professional. Titrate to clinical response. |
| 8-10 kg | 2.5 to 3.5 mg/kg (induction) | Single slow intravenous injection | Pediatric patients often require higher doses per kg compared to adults. Monitor oxygenation constantly. |
| 11-15 kg | 2.5 to 3.5 mg/kg (induction) | Single slow intravenous injection | Lower doses may be required for pediatric patients with compromised cardiorespiratory status. |
| 16-20 kg | 2.5 to 3.5 mg/kg (induction) | Single slow intravenous injection | Maintenance of anesthesia is typically achieved with a continuous infusion of 125 to 300 mcg/kg/min. |
Formulation
Purpose
Used for the induction and maintenance of general anesthesia, and for sedation in mechanically ventilated adults in intensive care units (ICU) or during diagnostic and surgical procedures.
Generic Name
PropofolBranded Drug Names
Propofol is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
No. This medicine is generally not treated as a scheduled/prescription-only drug in common consumer references, but local rules may vary.