Anidulafungin
Anidulafungin is a semi-synthetic echinocandic antifungal agent. It works by selectively inhibiting the synthesis of 1,3-beta-D-glucan, an essential component of the fungal cell wall, which is absent in mammalian cells. This leads to fungal cell lysis and death.
Dosage by Body Weight
Administered only by intravenous infusion. Adults: A single 200 mg loading dose on Day 1, followed by 100 mg daily thereafter. Pediatric patients (1 month to <18 years): Loading dose of 3.0 mg/kg (not to exceed 200 mg) on Day 1, followed by a maintenance dose of 1.5 mg/kg daily (not to exceed 100 mg). Duration of treatment is based on clinical response.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy in neonates and infants weighing less than 5 kg or under 1 month of age have not been established.
- Body Weight
- 5-7 kg
- Dose
- Loading: 15 to 21 mg on Day 1, then Maintenance: 7.5 to 10.5 mg daily
- Frequency
- Once daily
- Tracking Notes
- Based on pediatric dosing of 3 mg/kg loading dose followed by 1.5 mg/kg maintenance dose. Must be administered via slow IV infusion.
- Body Weight
- 8-10 kg
- Dose
- Loading: 24 to 30 mg on Day 1, then Maintenance: 12 to 15 mg daily
- Frequency
- Once daily
- Tracking Notes
- Infusion rate should not exceed 1.1 mg/minute to avoid infusion-associated reactions.
- Body Weight
- 11-15 kg
- Dose
- Loading: 33 to 45 mg on Day 1, then Maintenance: 16.5 to 22.5 mg daily
- Frequency
- Once daily
- Tracking Notes
- Reconstitute with sterile water for injection and dilute only with 0.9% Sodium Chloride or 5% Dextrose infusion.
- Body Weight
- 16-20 kg
- Dose
- Loading: 48 to 60 mg on Day 1, then Maintenance: 24 to 30 mg daily
- Frequency
- Once daily
- Tracking Notes
- Monitor liver function tests regularly during therapy.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Safety and efficacy in neonates and infants weighing less than 5 kg or under 1 month of age have not been established. |
| 5-7 kg | Loading: 15 to 21 mg on Day 1, then Maintenance: 7.5 to 10.5 mg daily | Once daily | Based on pediatric dosing of 3 mg/kg loading dose followed by 1.5 mg/kg maintenance dose. Must be administered via slow IV infusion. |
| 8-10 kg | Loading: 24 to 30 mg on Day 1, then Maintenance: 12 to 15 mg daily | Once daily | Infusion rate should not exceed 1.1 mg/minute to avoid infusion-associated reactions. |
| 11-15 kg | Loading: 33 to 45 mg on Day 1, then Maintenance: 16.5 to 22.5 mg daily | Once daily | Reconstitute with sterile water for injection and dilute only with 0.9% Sodium Chloride or 5% Dextrose infusion. |
| 16-20 kg | Loading: 48 to 60 mg on Day 1, then Maintenance: 24 to 30 mg daily | Once daily | Monitor liver function tests regularly during therapy. |
Formulation
Purpose
Treatment of invasive candidiasis (including candidemia) in adults and pediatric patients aged 1 month and older. It is also used for the treatment of esophageal candidiasis.
Generic Name
AnidulafunginBranded Drug Names
Anidulafungin is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.