Recovorin
Recovorin contains Leucovorin Calcium, which is a 5-formyl derivative of tetrahydrofolic acid. It is an active metabolite of folic acid and an essential coenzyme for nucleic acid synthesis in cytotoxic therapy. It is primarily used as a rescue agent after high-dose methotrexate therapy to protect healthy cells, and in combination with 5-fluorouracil to treat colorectal cancer.
Dosage by Body Weight
Dosage must be strictly individualized based on the patient's clinical status, body surface area, and plasma methotrexate levels. For methotrexate rescue, administration typically begins 24 hours after the start of methotrexate infusion. Always follow the specific protocol prescribed by an oncologist.
- Body Weight
- Below 5 kg
- Dose
- Dosed by BSA (mg/m²)
- Frequency
- As per oncologist protocol
- Tracking Notes
- Strictly determined by a pediatric oncologist based on body surface area and methotrexate clearance levels.
- Body Weight
- 5-7 kg
- Dose
- Dosed by BSA (mg/m²)
- Frequency
- As per oncologist protocol
- Tracking Notes
- Strictly determined by a pediatric oncologist based on body surface area and methotrexate clearance levels.
- Body Weight
- 8-10 kg
- Dose
- Dosed by BSA (mg/m²)
- Frequency
- As per oncologist protocol
- Tracking Notes
- Strictly determined by a pediatric oncologist based on body surface area and methotrexate clearance levels.
- Body Weight
- 11-15 kg
- Dose
- Dosed by BSA (mg/m²)
- Frequency
- As per oncologist protocol
- Tracking Notes
- Strictly determined by a pediatric oncologist based on body surface area and methotrexate clearance levels.
- Body Weight
- 16-20 kg
- Dose
- Dosed by BSA (mg/m²)
- Frequency
- As per oncologist protocol
- Tracking Notes
- Strictly determined by a pediatric oncologist based on body surface area and methotrexate clearance levels.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Dosed by BSA (mg/m²) | As per oncologist protocol | Strictly determined by a pediatric oncologist based on body surface area and methotrexate clearance levels. |
| 5-7 kg | Dosed by BSA (mg/m²) | As per oncologist protocol | Strictly determined by a pediatric oncologist based on body surface area and methotrexate clearance levels. |
| 8-10 kg | Dosed by BSA (mg/m²) | As per oncologist protocol | Strictly determined by a pediatric oncologist based on body surface area and methotrexate clearance levels. |
| 11-15 kg | Dosed by BSA (mg/m²) | As per oncologist protocol | Strictly determined by a pediatric oncologist based on body surface area and methotrexate clearance levels. |
| 16-20 kg | Dosed by BSA (mg/m²) | As per oncologist protocol | Strictly determined by a pediatric oncologist based on body surface area and methotrexate clearance levels. |
Formulation
Purpose
Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination or inadvertent overdosages of folic acid antagonists; also used in the treatment of megaloblastic anemias due to folate deficiency when oral therapy is not feasible, and in combination with 5-fluorouracil in palliative treatment of advanced colorectal cancer.
Generic Name
Leucovorin CalciumScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.