Folinic Acid (Leucovorin)
A derivative of folic acid that does not require the enzyme dihydrofolate reductase. It bypasses the block caused by certain drugs to protect healthy cells.
Dosage by Body Weight
With Pyrimethamine: 5–15 mg three times weekly. Timing is critical for methotrexate rescue.
- Body Weight
- Any weight
- Dose
- 5 mg to 15 mg
- Frequency
- As directed by oncologist
- Tracking Notes
- Critical for preventing dangerous drops in blood counts.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Any weight | 5 mg to 15 mg | As directed by oncologist | Critical for preventing dangerous drops in blood counts. |
Formulation
Purpose
Rescue therapy to prevent toxicity from Methotrexate or Pyrimethamine.
Generic Name
Calcium FolinateBranded Drug Names
Folinic Acid (Leucovorin) is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.
Alternatives
Safety Advice
Alcohol
CAUTIONFolinic Acid (Leucovorin): Alcohol can increase liver strain, stomach irritation, or immune-related complications. Avoid alcohol unless your specialist allows it.
Pregnancy
CAUTIONFolinic Acid (Leucovorin): Use in pregnancy only under specialist advice because immune, cancer, or transplant treatment requires careful risk assessment.
Breast Feeding
CAUTIONFolinic Acid (Leucovorin): Breastfeeding may not be recommended with some immunosuppressive or chemotherapy medicines. Follow specialist advice.
Driving
CAUTIONFolinic Acid (Leucovorin): May cause dizziness, fatigue, nausea, or weakness. Avoid driving if affected.
Liver
CAUTIONFolinic Acid (Leucovorin): Can affect liver function and usually requires regular blood tests. Use only with specialist monitoring.
Kidney
CAUTIONFolinic Acid (Leucovorin): Kidney function may need close monitoring, particularly with calcineurin inhibitors or high-risk regimens.