Syntran
Syntran contains Itraconazole, a triazole antifungal agent. It works by inhibiting the fungal cytochrome P450-dependent enzyme lanosterol 14-alpha-demethylase, which blocks the synthesis of ergosterol—an essential component of the fungal cell membrane. This disruption impairs cell membrane function and increases permeability, leading to fungal cell death.
Dosage by Body Weight
Syntran capsules should be swallowed whole immediately after a full meal to ensure maximum absorption. The dosage and duration of treatment depend on the type and severity of the fungal infection and must be prescribed by a healthcare provider.
- Body Weight
- Below 5 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Safety and efficacy have not been established in infants.
- Body Weight
- 5-7 kg
- Dose
- Not routinely recommended
- Frequency
- Use only if prescribed by a pediatric specialist
- Tracking Notes
- Requires specialized pediatric calculation, usually based on body surface area (BSA) rather than standard weight brackets.
- Body Weight
- 8-10 kg
- Dose
- Not routinely recommended
- Frequency
- Use only if prescribed by a pediatric specialist
- Tracking Notes
- Standard capsules (100mg) cannot be easily split or divided for pediatric dosing.
- Body Weight
- 11-15 kg
- Dose
- Not routinely recommended
- Frequency
- Use only if prescribed by a pediatric specialist
- Tracking Notes
- Alternative liquid formulations of Itraconazole may be preferred if available and clinically indicated.
- Body Weight
- 16-20 kg
- Dose
- Not routinely recommended
- Frequency
- Use only if prescribed by a pediatric specialist
- Tracking Notes
- Only administer under strict medical supervision and precise monitoring of hepatic function.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not recommended | N/A | Safety and efficacy have not been established in infants. |
| 5-7 kg | Not routinely recommended | Use only if prescribed by a pediatric specialist | Requires specialized pediatric calculation, usually based on body surface area (BSA) rather than standard weight brackets. |
| 8-10 kg | Not routinely recommended | Use only if prescribed by a pediatric specialist | Standard capsules (100mg) cannot be easily split or divided for pediatric dosing. |
| 11-15 kg | Not routinely recommended | Use only if prescribed by a pediatric specialist | Alternative liquid formulations of Itraconazole may be preferred if available and clinically indicated. |
| 16-20 kg | Not routinely recommended | Use only if prescribed by a pediatric specialist | Only administer under strict medical supervision and precise monitoring of hepatic function. |
Formulation
Purpose
Used for the treatment of various fungal infections, including systemic infections like aspergillosis, blastomycosis, and histoplasmosis, as well as superficial infections such as onychomycosis (nail fungus), oral candidiasis, and vulvovaginal candidiasis.
Generic Name
ItraconazoleScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.