Lopinavir
Lopinavir is an HIV-1 protease inhibitor. It is co-formulated with ritonavir, which acts as a pharmacokinetic booster by inhibiting CYP3A, thereby increasing the plasma concentrations of lopinavir.
Dosage by Body Weight
Must be taken in combination with ritonavir. Oral solution must be taken with food, whereas tablets can be taken with or without food. Dosages are highly individualized based on body weight, age, and concomitant therapies.
- Body Weight
- Below 5 kg
- Dose
- 16 mg/kg (Lopinavir component) / 4 mg/kg (Ritonavir component)
- Frequency
- Twice daily
- Tracking Notes
- Not recommended for neonates under 14 days of age. Use oral solution with food.
- Body Weight
- 5-7 kg
- Dose
- 1.0 mL to 1.25 mL oral solution (80/20 mg per mL)
- Frequency
- Twice daily
- Tracking Notes
- Provides approximately 80/20 mg to 100/25 mg of Lopinavir/Ritonavir. Must be administered with food.
- Body Weight
- 8-10 kg
- Dose
- 1.5 mL to 1.75 mL oral solution (80/20 mg per mL)
- Frequency
- Twice daily
- Tracking Notes
- Provides approximately 120/30 mg to 140/35 mg of Lopinavir/Ritonavir. Must be administered with food.
- Body Weight
- 11-15 kg
- Dose
- 2.0 mL to 2.5 mL oral solution OR 2 pediatric tablets (100/25 mg)
- Frequency
- Twice daily
- Tracking Notes
- Tablets must be swallowed whole and not chewed, broken, or crushed.
- Body Weight
- 16-20 kg
- Dose
- 3.0 mL oral solution OR 2 tablets (100/25 mg)
- Frequency
- Twice daily
- Tracking Notes
- Oral solution must be taken with food. Tablets can be taken with or without food.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 16 mg/kg (Lopinavir component) / 4 mg/kg (Ritonavir component) | Twice daily | Not recommended for neonates under 14 days of age. Use oral solution with food. |
| 5-7 kg | 1.0 mL to 1.25 mL oral solution (80/20 mg per mL) | Twice daily | Provides approximately 80/20 mg to 100/25 mg of Lopinavir/Ritonavir. Must be administered with food. |
| 8-10 kg | 1.5 mL to 1.75 mL oral solution (80/20 mg per mL) | Twice daily | Provides approximately 120/30 mg to 140/35 mg of Lopinavir/Ritonavir. Must be administered with food. |
| 11-15 kg | 2.0 mL to 2.5 mL oral solution OR 2 pediatric tablets (100/25 mg) | Twice daily | Tablets must be swallowed whole and not chewed, broken, or crushed. |
| 16-20 kg | 3.0 mL oral solution OR 2 tablets (100/25 mg) | Twice daily | Oral solution must be taken with food. Tablets can be taken with or without food. |
Formulation
Purpose
Used in combination with ritonavir and other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients.
Generic Name
Lopinavir / RitonavirBranded Drug Names
Lopinavir is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.