Darunavir
Darunavir is an HIV-1 protease inhibitor. It blocks the HIV protease enzyme, which prevents the virus from replicating and reduces the viral load in the body. It must always be taken with a pharmacokinetic enhancer (booster) such as ritonavir or cobicistat, alongside other antiretrovirals to prevent drug resistance.
Dosage by Body Weight
Adults: Typically 800 mg once daily with cobicistat 150 mg or ritonavir 100 mg, taken with food. For treatment-experienced adults with certain mutations, 600 mg twice daily with ritonavir 100 mg twice daily. Pediatric dosing is based on body weight and must be taken with ritonavir twice daily.
- Body Weight
- Below 5 kg
- Dose
- Contraindicated / Not recommended
- Frequency
- Do not administer
- Tracking Notes
- Not recommended for children under 10 kg or under 3 years of age due to toxicity risks.
- Body Weight
- 5-7 kg
- Dose
- Contraindicated / Not recommended
- Frequency
- Do not administer
- Tracking Notes
- Not recommended for children under 10 kg or under 3 years of age.
- Body Weight
- 8-10 kg
- Dose
- Contraindicated / Not recommended
- Frequency
- Do not administer
- Tracking Notes
- Generally contraindicated under 10 kg. Consult an HIV specialist if absolutely required.
- Body Weight
- 11-15 kg
- Dose
- 250 mg Darunavir (with 40 mg ritonavir)
- Frequency
- Twice daily
- Tracking Notes
- Must be administered with ritonavir and taken with food. Use oral suspension if tablets cannot be swallowed.
- Body Weight
- 16-20 kg
- Dose
- 375 mg Darunavir (with 50 mg ritonavir)
- Frequency
- Twice daily
- Tracking Notes
- Must be administered with ritonavir and taken with food.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Contraindicated / Not recommended | Do not administer | Not recommended for children under 10 kg or under 3 years of age due to toxicity risks. |
| 5-7 kg | Contraindicated / Not recommended | Do not administer | Not recommended for children under 10 kg or under 3 years of age. |
| 8-10 kg | Contraindicated / Not recommended | Do not administer | Generally contraindicated under 10 kg. Consult an HIV specialist if absolutely required. |
| 11-15 kg | 250 mg Darunavir (with 40 mg ritonavir) | Twice daily | Must be administered with ritonavir and taken with food. Use oral suspension if tablets cannot be swallowed. |
| 16-20 kg | 375 mg Darunavir (with 50 mg ritonavir) | Twice daily | Must be administered with ritonavir and taken with food. |
Formulation
Purpose
Used in combination with other antiretroviral medications (boosted with ritonavir or cobicistat) to treat Human Immunodeficiency Virus Type 1 (HIV-1) infection in adults and pediatric patients aged 3 years and older.
Generic Name
DarunavirBranded Drug Names
Darunavir is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.