Genticyn
Genticyn contains Gentamicin, a potent aminoglycoside antibiotic. It acts by binding to the bacterial 30S ribosomal subunit, inhibiting protein synthesis and causing bacterial cell death. It is highly active against aerobic gram-negative bacteria and some gram-positive organisms.
Dosage by Body Weight
For ophthalmic/otic use, typically 1 to 2 drops are instilled into the affected eye or ear every 4 hours. For systemic injection, dosing must be strictly individualized by a healthcare professional based on body weight, renal function, and serum gentamicin levels to prevent ototoxicity and nephrotoxicity.
- Body Weight
- Below 5 kg
- Dose
- Strictly calculated based on gestational age and renal function
- Frequency
- Every 12 to 24 hours
- Tracking Notes
- Neonates require close therapeutic drug monitoring to avoid toxicity.
- Body Weight
- 5-7 kg
- Dose
- 10 mg to 17.5 mg (based on 2 to 2.5 mg/kg per dose)
- Frequency
- Every 8 to 12 hours
- Tracking Notes
- Must be administered via IV infusion or IM injection under medical supervision.
- Body Weight
- 8-10 kg
- Dose
- 16 mg to 25 mg (based on 2 to 2.5 mg/kg per dose)
- Frequency
- Every 8 to 12 hours
- Tracking Notes
- Ensure hydration status is adequate during treatment.
- Body Weight
- 11-15 kg
- Dose
- 22 mg to 37.5 mg (based on 2 to 2.5 mg/kg per dose)
- Frequency
- Every 8 to 12 hours
- Tracking Notes
- Monitor kidney function indicators (serum creatinine) during prolonged therapy.
- Body Weight
- 16-20 kg
- Dose
- 32 mg to 50 mg (based on 2 to 2.5 mg/kg per dose)
- Frequency
- Every 8 to 12 hours
- Tracking Notes
- Dose adjustments required in children with pre-existing renal impairment.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Strictly calculated based on gestational age and renal function | Every 12 to 24 hours | Neonates require close therapeutic drug monitoring to avoid toxicity. |
| 5-7 kg | 10 mg to 17.5 mg (based on 2 to 2.5 mg/kg per dose) | Every 8 to 12 hours | Must be administered via IV infusion or IM injection under medical supervision. |
| 8-10 kg | 16 mg to 25 mg (based on 2 to 2.5 mg/kg per dose) | Every 8 to 12 hours | Ensure hydration status is adequate during treatment. |
| 11-15 kg | 22 mg to 37.5 mg (based on 2 to 2.5 mg/kg per dose) | Every 8 to 12 hours | Monitor kidney function indicators (serum creatinine) during prolonged therapy. |
| 16-20 kg | 32 mg to 50 mg (based on 2 to 2.5 mg/kg per dose) | Every 8 to 12 hours | Dose adjustments required in children with pre-existing renal impairment. |
Formulation
Purpose
Used to treat bacterial infections of the eye (such as conjunctivitis, blepharitis), external ear infections (otitis externa), and severe systemic bacterial infections like septicemia, meningitis, and urinary tract infections.
Generic Name
GentamicinScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.