Garamycin
Garamycin is an aminoglycoside antibiotic containing Gentamicin. It works by inhibiting bacterial protein synthesis, making it highly effective against severe Gram-negative infections. Due to potential risks of ototoxicity and nephrotoxicity, therapy requires careful monitoring of renal function and serum drug levels.
Dosage by Body Weight
Dosage must be highly individualized based on body weight, renal function, and serum drug concentration levels. Typically administered via intramuscular (IM) or intravenous (IV) injection, or applied topically for skin/eye infections.
- Body Weight
- Below 5 kg
- Dose
- 2.5 mg/kg per dose
- Frequency
- Every 12 to 24 hours
- Tracking Notes
- Primarily for neonates; dose interval depends heavily on gestational and post-natal age. Serum level monitoring is mandatory.
- Body Weight
- 5-7 kg
- Dose
- 10 mg to 17.5 mg per dose (calculated at 2 to 2.5 mg/kg)
- Frequency
- Every 8 hours
- Tracking Notes
- Adjust dosage interval in patients with renal impairment. Monitor kidney function.
- Body Weight
- 8-10 kg
- Dose
- 16 mg to 25 mg per dose (calculated at 2 to 2.5 mg/kg)
- Frequency
- Every 8 hours
- Tracking Notes
- Maintain adequate hydration during therapy to minimize renal toxicity risk.
- Body Weight
- 11-15 kg
- Dose
- 22 mg to 37.5 mg per dose (calculated at 2 to 2.5 mg/kg)
- Frequency
- Every 8 hours
- Tracking Notes
- Perform regular audiometric testing if therapy extends beyond 7-10 days.
- Body Weight
- 16-20 kg
- Dose
- 32 mg to 50 mg per dose (calculated at 2 to 2.5 mg/kg)
- Frequency
- Every 8 hours
- Tracking Notes
- Ensure peak serum concentrations do not exceed 10 mcg/mL and trough concentrations remain below 2 mcg/mL.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 2.5 mg/kg per dose | Every 12 to 24 hours | Primarily for neonates; dose interval depends heavily on gestational and post-natal age. Serum level monitoring is mandatory. |
| 5-7 kg | 10 mg to 17.5 mg per dose (calculated at 2 to 2.5 mg/kg) | Every 8 hours | Adjust dosage interval in patients with renal impairment. Monitor kidney function. |
| 8-10 kg | 16 mg to 25 mg per dose (calculated at 2 to 2.5 mg/kg) | Every 8 hours | Maintain adequate hydration during therapy to minimize renal toxicity risk. |
| 11-15 kg | 22 mg to 37.5 mg per dose (calculated at 2 to 2.5 mg/kg) | Every 8 hours | Perform regular audiometric testing if therapy extends beyond 7-10 days. |
| 16-20 kg | 32 mg to 50 mg per dose (calculated at 2 to 2.5 mg/kg) | Every 8 hours | Ensure peak serum concentrations do not exceed 10 mcg/mL and trough concentrations remain below 2 mcg/mL. |
Formulation
Purpose
Treatment of severe bacterial infections including septicemia, meningitis, urinary tract infections, respiratory tract infections, and local skin or eye infections.
Generic Name
GentamicinScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.