Epitrogene
Epitrogene contains Lamotrigine, an antiepileptic drug (AED) belonging to the phenyltriazine class. It works by inhibiting voltage-sensitive sodium channels, stabilizing neuronal membranes, and modulating the release of excitatory neurotransmitters such as glutamate.
Dosage by Body Weight
Dosage must be customized and escalated extremely slowly over several weeks to minimize the risk of severe, life-threatening skin rashes (such as Stevens-Johnson syndrome). Dose titration is highly dependent on whether the patient is concurrently taking valproate (enzyme inhibitor) or carbamazepine/phenytoin (enzyme inducers). Always follow precise physician instructions.
- Body Weight
- Below 5 kg
- Dose
- Not recommended
- Frequency
- Do not use
- Tracking Notes
- Safety and efficacy have not been established in patients weighing less than 5 kg.
- Body Weight
- 5-7 kg
- Dose
- 0.15 mg to 0.6 mg per day (initial dose range)
- Frequency
- Once daily or split into two doses
- Tracking Notes
- Starting dose depends heavily on concomitant antiepileptic drugs. Must be titrated very slowly.
- Body Weight
- 8-10 kg
- Dose
- 0.3 mg to 1.0 mg per day (initial dose range)
- Frequency
- Once daily or split into two doses
- Tracking Notes
- Monitor closely for rashes. Maintenance doses will be progressively higher after multi-week titration.
- Body Weight
- 11-15 kg
- Dose
- 1.5 mg to 5.0 mg per day (initial titration dose)
- Frequency
- Once or twice daily
- Tracking Notes
- Use dispersible/chewable formulations to achieve exact pediatric weight-based dosing.
- Body Weight
- 16-20 kg
- Dose
- 2.0 mg to 10 mg per day (initial titration dose)
- Frequency
- Once or twice daily
- Tracking Notes
- Maintenance dose will be determined by clinical response and co-medications under strict medical supervision.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not recommended | Do not use | Safety and efficacy have not been established in patients weighing less than 5 kg. |
| 5-7 kg | 0.15 mg to 0.6 mg per day (initial dose range) | Once daily or split into two doses | Starting dose depends heavily on concomitant antiepileptic drugs. Must be titrated very slowly. |
| 8-10 kg | 0.3 mg to 1.0 mg per day (initial dose range) | Once daily or split into two doses | Monitor closely for rashes. Maintenance doses will be progressively higher after multi-week titration. |
| 11-15 kg | 1.5 mg to 5.0 mg per day (initial titration dose) | Once or twice daily | Use dispersible/chewable formulations to achieve exact pediatric weight-based dosing. |
| 16-20 kg | 2.0 mg to 10 mg per day (initial titration dose) | Once or twice daily | Maintenance dose will be determined by clinical response and co-medications under strict medical supervision. |
Formulation
Purpose
Used to treat epilepsy (including partial seizures, generalized tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome) and for the maintenance treatment of Bipolar I Disorder to delay mood episodes.
Generic Name
LamotrigineScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.