Amphotec
Amphotec is an antifungal agent consisting of a 1:1 molar ratio complex of amphotericin B and sodium cholesteryl sulfate. It is formulated as a sterile, pyrogen-free lyophilized powder for reconstitution and intravenous infusion.
Dosage by Body Weight
The recommended dose for adults and pediatric patients is 3 to 4 mg/kg/day, administered by intravenous infusion at a rate of 1 mg/kg/hour. Reconstitute only with Sterile Water for Injection, and dilute only with 5% Dextrose Injection.
- Body Weight
- Below 5 kg
- Dose
- 3 to 4 mg/kg (up to 16 mg)
- Frequency
- Once daily
- Tracking Notes
- Administer via IV infusion over 2 hours. Monitor renal and hepatic function closely.
- Body Weight
- 5-7 kg
- Dose
- 15 to 28 mg
- Frequency
- Once daily
- Tracking Notes
- Administer via IV infusion over 2 hours. Premedication with antihistamines or antipyretics may prevent infusion-related reactions.
- Body Weight
- 8-10 kg
- Dose
- 24 to 40 mg
- Frequency
- Once daily
- Tracking Notes
- Administer via IV infusion over 2 hours. Regularly monitor serum potassium and magnesium levels.
- Body Weight
- 11-15 kg
- Dose
- 33 to 60 mg
- Frequency
- Once daily
- Tracking Notes
- Administer via IV infusion over 2 hours. Do not use an in-line filter with a pore size of less than 1.0 micron.
- Body Weight
- 16-20 kg
- Dose
- 48 to 80 mg
- Frequency
- Once daily
- Tracking Notes
- Administer via IV infusion over 2 hours. Avoid mixing or co-infusing with other medications.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 3 to 4 mg/kg (up to 16 mg) | Once daily | Administer via IV infusion over 2 hours. Monitor renal and hepatic function closely. |
| 5-7 kg | 15 to 28 mg | Once daily | Administer via IV infusion over 2 hours. Premedication with antihistamines or antipyretics may prevent infusion-related reactions. |
| 8-10 kg | 24 to 40 mg | Once daily | Administer via IV infusion over 2 hours. Regularly monitor serum potassium and magnesium levels. |
| 11-15 kg | 33 to 60 mg | Once daily | Administer via IV infusion over 2 hours. Do not use an in-line filter with a pore size of less than 1.0 micron. |
| 16-20 kg | 48 to 80 mg | Once daily | Administer via IV infusion over 2 hours. Avoid mixing or co-infusing with other medications. |
Formulation
Purpose
Treatment of invasive aspergillosis in patients where renal toxicity or anemia precludes the use of amphotericin B deoxycholate in effective doses, or in patients who have failed amphotericin B deoxycholate therapy.
Generic Name
Amphotericin B Cholesteryl Sulfate ComplexScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.