Fungizone
Fungizone is a brand name for Amphotericin B, a potent antifungal medication. It is reserved for severe, systemic fungal infections due to its potential for serious side effects, particularly renal toxicity. It works by disrupting the fungal cell membrane.
Dosage by Body Weight
Dosage must be highly individualized and administered under strict medical supervision, usually in a hospital setting. Typically initiated with a test dose, followed by daily doses of 0.25 to 1.5 mg/kg/day administered via slow intravenous infusion over 2 to 6 hours.
- Body Weight
- Below 5 kg
- Dose
- 0.25 to 1 mg/kg/day
- Frequency
- Once daily
- Tracking Notes
- Neonatal dosing requires extreme caution and close monitoring of renal function.
- Body Weight
- 5-7 kg
- Dose
- 1.25 to 7 mg daily
- Frequency
- Once daily
- Tracking Notes
- Calculated at 0.25 - 1 mg/kg/day. Administer via slow IV infusion.
- Body Weight
- 8-10 kg
- Dose
- 2 to 10 mg daily
- Frequency
- Once daily
- Tracking Notes
- Calculated at 0.25 - 1 mg/kg/day. Monitor electrolytes and kidney function closely.
- Body Weight
- 11-15 kg
- Dose
- 2.75 to 15 mg daily
- Frequency
- Once daily
- Tracking Notes
- Calculated at 0.25 - 1 mg/kg/day. Pre-medications may be used to prevent infusion reactions.
- Body Weight
- 16-20 kg
- Dose
- 4 to 20 mg daily
- Frequency
- Once daily
- Tracking Notes
- Calculated at 0.25 - 1 mg/kg/day. Ensure adequate saline hydration before infusion.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 0.25 to 1 mg/kg/day | Once daily | Neonatal dosing requires extreme caution and close monitoring of renal function. |
| 5-7 kg | 1.25 to 7 mg daily | Once daily | Calculated at 0.25 - 1 mg/kg/day. Administer via slow IV infusion. |
| 8-10 kg | 2 to 10 mg daily | Once daily | Calculated at 0.25 - 1 mg/kg/day. Monitor electrolytes and kidney function closely. |
| 11-15 kg | 2.75 to 15 mg daily | Once daily | Calculated at 0.25 - 1 mg/kg/day. Pre-medications may be used to prevent infusion reactions. |
| 16-20 kg | 4 to 20 mg daily | Once daily | Calculated at 0.25 - 1 mg/kg/day. Ensure adequate saline hydration before infusion. |
Formulation
Purpose
Treatment of severe, progressive, and potentially life-threatening systemic fungal infections and severe oral candidiasis.
Generic Name
Amphotericin BScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.