Domperidone
Domperidone increases movements or contractions of the stomach and bowel. It also blocks dopamine receptors in the brain to reduce nausea.
Dosage by Body Weight
Use in children is restricted in some regions due to cardiac risk. Dosage must be strictly weight-based (0.25 mg/kg up to 3 times daily).
- Body Weight
- 5-10 kg
- Dose
- 1.25-2.5 mg
- Frequency
- Up to 3 times daily
- Tracking Notes
- Administer 15-30 minutes before food.
- Body Weight
- 11-20 kg
- Dose
- 2.75-5 mg
- Frequency
- Up to 3 times daily
- Tracking Notes
- Use the lowest effective dose for the shortest duration.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| 5-10 kg | 1.25-2.5 mg | Up to 3 times daily | Administer 15-30 minutes before food. |
| 11-20 kg | 2.75-5 mg | Up to 3 times daily | Use the lowest effective dose for the shortest duration. |
Formulation
Purpose
Antiemetic and prokinetic agent used to treat nausea and vomiting, and to increase breast milk production (off-label).
Generic Name
DomperidoneBranded Drug Names
Domperidone is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.
Alternatives
Safety Advice
Alcohol
CAUTIONAlcohol may increase dizziness or heart rhythm concerns with domperidone. Avoid alcohol unless your healthcare provider says it is safe.
Pregnancy
CAUTIONDomperidone should be used during pregnancy only when clearly prescribed, as safety data are limited and cardiac risks must be considered.
Breast Feeding
CAUTIONDomperidone can pass into breast milk and is sometimes used off-label for lactation, but it carries cardiac risk. Use only under medical supervision.
Driving
SAFEDomperidone usually has minimal effect on alertness, but dizziness can occur. Avoid driving if you feel dizzy or faint.
Liver
CAUTIONDomperidone is not recommended in moderate to severe liver impairment due to increased risk of side effects.
Kidney
CAUTIONDomperidone may require reduced dosing frequency in kidney impairment. Use only with healthcare provider guidance.