Zycortal
Zycortal (desoxycorticosterone pivalate) is a prolonged-release injectable suspension used to replace mineralocorticoid hormones in dogs suffering from primary hypoadrenocorticism (Addison's disease). It helps control sodium and potassium balance in the body.
Dosage by Body Weight
The initial starting dose is 2.2 mg/kg (1 mg/lb) body weight administered subcutaneously. Dosage and interval are adjusted based on clinical signs and serum sodium/potassium ratios measured approximately 10 days and 25 days after administration.
- Body Weight
- Below 5 kg
- Dose
- Up to 11 mg (Up to 0.44 mL)
- Frequency
- Every 25 days
- Tracking Notes
- Dose calculated at 2.2 mg/kg. Exact dosing should be determined by a veterinarian based on precise weight.
- Body Weight
- 5-7 kg
- Dose
- 11 to 15.4 mg (0.44 to 0.62 mL)
- Frequency
- Every 25 days
- Tracking Notes
- Monitor serum electrolytes at day 10 and day 25 post-injection to adjust dose or interval.
- Body Weight
- 8-10 kg
- Dose
- 17.6 to 22 mg (0.7 to 0.88 mL)
- Frequency
- Every 25 days
- Tracking Notes
- Administer subcutaneously. Shake vial vigorously before use to resuspend.
- Body Weight
- 11-15 kg
- Dose
- 24.2 to 33 mg (0.97 to 1.32 mL)
- Frequency
- Every 25 days
- Tracking Notes
- Adjustments are typically made in increments or decrements of 10% based on clinical response.
- Body Weight
- 16-20 kg
- Dose
- 35.2 to 44 mg (1.41 to 1.76 mL)
- Frequency
- Every 25 days
- Tracking Notes
- Monitor for potential side effects such as polyuria, polydipsia, or injection site reactions.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Up to 11 mg (Up to 0.44 mL) | Every 25 days | Dose calculated at 2.2 mg/kg. Exact dosing should be determined by a veterinarian based on precise weight. |
| 5-7 kg | 11 to 15.4 mg (0.44 to 0.62 mL) | Every 25 days | Monitor serum electrolytes at day 10 and day 25 post-injection to adjust dose or interval. |
| 8-10 kg | 17.6 to 22 mg (0.7 to 0.88 mL) | Every 25 days | Administer subcutaneously. Shake vial vigorously before use to resuspend. |
| 11-15 kg | 24.2 to 33 mg (0.97 to 1.32 mL) | Every 25 days | Adjustments are typically made in increments or decrements of 10% based on clinical response. |
| 16-20 kg | 35.2 to 44 mg (1.41 to 1.76 mL) | Every 25 days | Monitor for potential side effects such as polyuria, polydipsia, or injection site reactions. |
Formulation
Injectable Suspension
Purpose
Mineralocorticoid replacement therapy for dogs with primary hypoadrenocorticism (Addison's disease)
Generic Name
Desoxycorticosterone pivalateScheduled Drug
No. This medicine is generally not treated as a scheduled/prescription-only drug in common consumer references, but local rules may vary.