Vitamin K1
Vitamin K1, also known as phylloquinone or phytomenadione, is a fat-soluble vitamin essential for the hepatic synthesis of blood coagulation factors II (prothrombin), VII, IX, and X. It is critical for maintaining healthy blood clotting and preventing severe bleeding.
Dosage by Body Weight
Dosage is highly individualized based on age, clinical indication, and coagulation profile (INR). For newborn prophylaxis, a single intramuscular dose is standard. For anticoagulant reversal or deficiency in pediatric populations, consult a physician.
- Body Weight
- Below 5 kg
- Dose
- 0.5 mg to 1 mg (IM) or 2 mg (oral)
- Frequency
- Single dose at birth
- Tracking Notes
- Standard prophylaxis for Vitamin K Deficiency Bleeding (VKDB) in newborns. Oral regimen may require repeat doses at 1 and 4 weeks.
- Body Weight
- 5-7 kg
- Dose
- Based on clinical indication
- Frequency
- As directed by physician
- Tracking Notes
- Used under strict medical supervision. Dose adjusted based on PT/INR levels.
- Body Weight
- 8-10 kg
- Dose
- Based on clinical indication
- Frequency
- As directed by physician
- Tracking Notes
- Dose titrated depending on severity of deficiency or anticoagulant reversal requirements.
- Body Weight
- 11-15 kg
- Dose
- Based on clinical indication
- Frequency
- As directed by physician
- Tracking Notes
- Monitor coagulation parameters regularly during therapy.
- Body Weight
- 16-20 kg
- Dose
- Based on clinical indication
- Frequency
- As directed by physician
- Tracking Notes
- Oral or parenteral routes chosen based on severity of bleeding risk.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 0.5 mg to 1 mg (IM) or 2 mg (oral) | Single dose at birth | Standard prophylaxis for Vitamin K Deficiency Bleeding (VKDB) in newborns. Oral regimen may require repeat doses at 1 and 4 weeks. |
| 5-7 kg | Based on clinical indication | As directed by physician | Used under strict medical supervision. Dose adjusted based on PT/INR levels. |
| 8-10 kg | Based on clinical indication | As directed by physician | Dose titrated depending on severity of deficiency or anticoagulant reversal requirements. |
| 11-15 kg | Based on clinical indication | As directed by physician | Monitor coagulation parameters regularly during therapy. |
| 16-20 kg | Based on clinical indication | As directed by physician | Oral or parenteral routes chosen based on severity of bleeding risk. |
Formulation
Purpose
Prevention and treatment of vitamin K deficiency bleeding (hemorrhagic disease of the newborn), hypoprothrombinemia induced by oral anticoagulants, and nutritional vitamin K deficiency.
Generic Name
PhytomenadioneBranded Drug Names
Vitamin K1 is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
No. This medicine is generally not treated as a scheduled/prescription-only drug in common consumer references, but local rules may vary.