Vigabatrin
Irreversibly inhibits GABA transaminase, increasing GABA levels in the brain. **Warning: Can cause permanent peripheral vision loss.**
Dosage by Body Weight
Infantile spasms: Start 50 mg/kg/day, titrated up to 150 mg/kg/day. Requires regular vision testing (ERGs).
- Body Weight
- 5-10 kg
- Dose
- 250 mg to 500 mg
- Frequency
- Twice daily
- Tracking Notes
- Available as sachets to be dissolved in water or juice.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| 5-10 kg | 250 mg to 500 mg | Twice daily | Available as sachets to be dissolved in water or juice. |
Formulation
Powder for Oral SolutionTablet
Purpose
Treatment of infantile spasms (West Syndrome) and refractory focal seizures.
Generic Name
Vigabatrin
Branded Drug Names
Vigabatrin is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
- Sabril
- Vigadexa
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.
Alternatives
ACTHTopiramate