Vigabatrin
Irreversibly inhibits GABA transaminase, increasing GABA levels in the brain. **Warning: Can cause permanent peripheral vision loss.**
Dosage by Body Weight
Infantile spasms: Start 50 mg/kg/day, titrated up to 150 mg/kg/day. Requires regular vision testing (ERGs).
- Body Weight
- 5-10 kg
- Dose
- 250 mg to 500 mg
- Frequency
- Twice daily
- Tracking Notes
- Available as sachets to be dissolved in water or juice.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| 5-10 kg | 250 mg to 500 mg | Twice daily | Available as sachets to be dissolved in water or juice. |
Formulation
Purpose
Treatment of infantile spasms (West Syndrome) and refractory focal seizures.
Generic Name
VigabatrinBranded Drug Names
Vigabatrin is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.
Alternatives
Safety Advice
Alcohol
UNSAFEVigabatrin: Alcohol can significantly increase drowsiness, dizziness, breathing problems, or seizure risk. Avoid alcohol unless a specialist says otherwise.
Pregnancy
CAUTIONVigabatrin: Use in pregnancy only under specialist advice because seizure control and fetal risks must be carefully balanced.
Breast Feeding
SAFE IF PRESCRIBEDVigabatrin: May pass into breast milk and can cause infant drowsiness or feeding issues. Use only with healthcare provider guidance.
Driving
CAUTIONVigabatrin: Can cause drowsiness, slowed reaction time, dizziness, or blurred vision. Avoid driving until you know how it affects you.
Liver
CAUTIONVigabatrin: Some anti-seizure medicines can affect liver function and may require blood tests or dose adjustments.
Kidney
CAUTIONVigabatrin: Some anti-seizure medicines require dose adjustment in kidney impairment. Use under medical supervision.