Sabril
Sabril (vigabatrin) is an antiepileptic medication that works by irreversibly inhibiting the enzyme GABA transaminase, which increases GABA levels in the brain. It carries a boxed warning due to the risk of permanent vision loss (bilateral concentric visual field constriction) and is only accessible through a restricted REMS program.
Dosage by Body Weight
For infantile spasms, the standard starting dose is 50 mg/kg/day split into two daily doses, which can be titrated up to 150 mg/kg/day. For refractory complex partial seizures, the recommended adult starting dose is 1000 mg/day (500 mg twice daily) up to a maximum of 3000 mg/day.
- Body Weight
- Below 5 kg
- Dose
- 150 mg to 600 mg daily
- Frequency
- Two divided doses daily
- Tracking Notes
- Calculated based on 50 mg/kg/day starting dose up to 150 mg/kg/day maximum. Must be titrated gradually.
- Body Weight
- 5-7 kg
- Dose
- 250 mg to 1050 mg daily
- Frequency
- Two divided doses daily
- Tracking Notes
- Calculated based on 50 mg/kg/day starting dose up to 150 mg/kg/day maximum. Titrate weekly based on response.
- Body Weight
- 8-10 kg
- Dose
- 400 mg to 1500 mg daily
- Frequency
- Two divided doses daily
- Tracking Notes
- Calculated based on 50 mg/kg/day starting dose up to 150 mg/kg/day maximum. Regular ophthalmic monitoring required.
- Body Weight
- 11-15 kg
- Dose
- 550 mg to 2250 mg daily
- Frequency
- Two divided doses daily
- Tracking Notes
- Calculated based on 50 mg/kg/day starting dose up to 150 mg/kg/day maximum. Dissolve powder in cold or room temperature water.
- Body Weight
- 16-20 kg
- Dose
- 800 mg to 3000 mg daily
- Frequency
- Two divided doses daily
- Tracking Notes
- Calculated based on 50 mg/kg/day starting dose up to 150 mg/kg/day maximum. Do not exceed the maximum adult dosage of 3000 mg/day.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 150 mg to 600 mg daily | Two divided doses daily | Calculated based on 50 mg/kg/day starting dose up to 150 mg/kg/day maximum. Must be titrated gradually. |
| 5-7 kg | 250 mg to 1050 mg daily | Two divided doses daily | Calculated based on 50 mg/kg/day starting dose up to 150 mg/kg/day maximum. Titrate weekly based on response. |
| 8-10 kg | 400 mg to 1500 mg daily | Two divided doses daily | Calculated based on 50 mg/kg/day starting dose up to 150 mg/kg/day maximum. Regular ophthalmic monitoring required. |
| 11-15 kg | 550 mg to 2250 mg daily | Two divided doses daily | Calculated based on 50 mg/kg/day starting dose up to 150 mg/kg/day maximum. Dissolve powder in cold or room temperature water. |
| 16-20 kg | 800 mg to 3000 mg daily | Two divided doses daily | Calculated based on 50 mg/kg/day starting dose up to 150 mg/kg/day maximum. Do not exceed the maximum adult dosage of 3000 mg/day. |
Formulation
Purpose
Used as adjunctive therapy for adults and pediatric patients 2 years of age and older with refractory complex partial seizures, and as monotherapy for infantile spasms in infants 1 month to 2 years of age.
Generic Name
VigabatrinScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.