Neoral
Neoral is an immunosuppressive agent containing cyclosporine formulated as a microemulsion. It works by suppressing the immune system's T-cells to prevent the body from rejecting transplanted organs or to reduce inflammation in severe autoimmune conditions like rheumatoid arthritis and psoriasis.
Dosage by Body Weight
Dosage must be highly individualized and adjusted based on blood trough levels of cyclosporine, organ type, and clinical response. Usually administered in two divided doses daily on a consistent schedule relative to meals.
- Body Weight
- Below 5 kg
- Dose
- Highly individualized (Typically 5-15 mg/kg/day divided into 2 doses)
- Frequency
- Twice daily (Every 12 hours)
- Tracking Notes
- Not routinely used in infants under 5 kg without strict specialist supervision and blood level monitoring.
- Body Weight
- 5-7 kg
- Dose
- 12.5 mg to 50 mg twice daily
- Frequency
- Twice daily (Every 12 hours)
- Tracking Notes
- Starting doses vary based on transplant type. Frequent blood level monitoring is mandatory to adjust dose.
- Body Weight
- 8-10 kg
- Dose
- 20 mg to 75 mg twice daily
- Frequency
- Twice daily (Every 12 hours)
- Tracking Notes
- Dose must be titrated based on therapeutic drug monitoring to prevent toxicity or organ rejection.
- Body Weight
- 11-15 kg
- Dose
- 27.5 mg to 110 mg twice daily
- Frequency
- Twice daily (Every 12 hours)
- Tracking Notes
- Consistent administration with or without food is necessary to maintain stable blood concentrations.
- Body Weight
- 16-20 kg
- Dose
- 40 mg to 150 mg twice daily
- Frequency
- Twice daily (Every 12 hours)
- Tracking Notes
- Target trough levels must be evaluated regularly. Avoid consuming grapefruit or grapefruit juice.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Highly individualized (Typically 5-15 mg/kg/day divided into 2 doses) | Twice daily (Every 12 hours) | Not routinely used in infants under 5 kg without strict specialist supervision and blood level monitoring. |
| 5-7 kg | 12.5 mg to 50 mg twice daily | Twice daily (Every 12 hours) | Starting doses vary based on transplant type. Frequent blood level monitoring is mandatory to adjust dose. |
| 8-10 kg | 20 mg to 75 mg twice daily | Twice daily (Every 12 hours) | Dose must be titrated based on therapeutic drug monitoring to prevent toxicity or organ rejection. |
| 11-15 kg | 27.5 mg to 110 mg twice daily | Twice daily (Every 12 hours) | Consistent administration with or without food is necessary to maintain stable blood concentrations. |
| 16-20 kg | 40 mg to 150 mg twice daily | Twice daily (Every 12 hours) | Target trough levels must be evaluated regularly. Avoid consuming grapefruit or grapefruit juice. |
Formulation
Purpose
To prevent organ rejection following kidney, liver, or heart transplantation, and to treat severe rheumatoid arthritis and plaque psoriasis.
Generic Name
Cyclosporine (Microemulsion)Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.