Sandimmune
Sandimmune is an immunosuppressant medicine containing cyclosporine (non-modified). It is a calcineurin inhibitor used primarily to prevent the body from rejecting a newly transplanted kidney, liver, or heart. Because of differences in bioavailability, Sandimmune is not bioequivalent to and cannot be used interchangeably with Neoral or Gengraf without medical supervision.
Dosage by Body Weight
Dosage must be individualized for each patient based on clinical response, tolerability, and blood concentration levels. The daily dose is typically administered in two divided doses on a consistent schedule with regard to time of day and meals.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed by a specialist
- Tracking Notes
- Highly specialized dosing requiring frequent therapeutic drug monitoring of blood trough levels.
- Body Weight
- 5-7 kg
- Dose
- 25 mg to 50 mg daily, divided
- Frequency
- Every 12 hours
- Tracking Notes
- Based on a maintenance range of 5-10 mg/kg/day. Exact dose must be determined by blood level monitoring.
- Body Weight
- 8-10 kg
- Dose
- 40 mg to 75 mg daily, divided
- Frequency
- Every 12 hours
- Tracking Notes
- Based on a maintenance range of 5-10 mg/kg/day. Exact dose must be determined by blood level monitoring.
- Body Weight
- 11-15 kg
- Dose
- 55 mg to 110 mg daily, divided
- Frequency
- Every 12 hours
- Tracking Notes
- Based on a maintenance range of 5-10 mg/kg/day. Exact dose must be determined by blood level monitoring.
- Body Weight
- 16-20 kg
- Dose
- 80 mg to 150 mg daily, divided
- Frequency
- Every 12 hours
- Tracking Notes
- Based on a maintenance range of 5-10 mg/kg/day. Exact dose must be determined by blood level monitoring.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed by a specialist | Highly specialized dosing requiring frequent therapeutic drug monitoring of blood trough levels. |
| 5-7 kg | 25 mg to 50 mg daily, divided | Every 12 hours | Based on a maintenance range of 5-10 mg/kg/day. Exact dose must be determined by blood level monitoring. |
| 8-10 kg | 40 mg to 75 mg daily, divided | Every 12 hours | Based on a maintenance range of 5-10 mg/kg/day. Exact dose must be determined by blood level monitoring. |
| 11-15 kg | 55 mg to 110 mg daily, divided | Every 12 hours | Based on a maintenance range of 5-10 mg/kg/day. Exact dose must be determined by blood level monitoring. |
| 16-20 kg | 80 mg to 150 mg daily, divided | Every 12 hours | Based on a maintenance range of 5-10 mg/kg/day. Exact dose must be determined by blood level monitoring. |
Formulation
Purpose
Prophylaxis of organ rejection in kidney, liver, and heart allogeneic transplants, and treatment of chronic rejection in patients previously treated with other immunosuppressive agents.
Generic Name
Cyclosporine (non-modified)Scheduled Drug
No. This medicine is generally not treated as a scheduled/prescription-only drug in common consumer references, but local rules may vary.