Plasmotrim
Plasmotrim contains Artesunate, a water-soluble artemisinin derivative. It is a highly potent antimalarial drug that rapidly clears malaria parasites from the bloodstream. It is primarily utilized in the critical management of severe malaria cases, often administered intravenously or intramuscularly before transitioning to oral artemisinin-based combination therapy (ACT).
Dosage by Body Weight
Dosage must be determined by a healthcare provider. For severe malaria, the World Health Organization (WHO) recommends intravenous or intramuscular administration. Children weighing less than 20 kg should receive a higher relative dose (3 mg/kg per dose) compared to larger children and adults (2.4 mg/kg per dose).
- Body Weight
- Below 5 kg
- Dose
- 15 mg (calculated at 3 mg/kg)
- Frequency
- At 0, 12, and 24 hours, then once daily
- Tracking Notes
- Administer intravenously or intramuscularly under strict hospital supervision.
- Body Weight
- 5-7 kg
- Dose
- 15 mg to 21 mg
- Frequency
- At 0, 12, and 24 hours, then once daily
- Tracking Notes
- Based on the pediatric dosing guideline of 3 mg/kg.
- Body Weight
- 8-10 kg
- Dose
- 24 mg to 30 mg
- Frequency
- At 0, 12, and 24 hours, then once daily
- Tracking Notes
- Ensure complete dissolution of the injection vial using the provided solvent.
- Body Weight
- 11-15 kg
- Dose
- 33 mg to 45 mg
- Frequency
- At 0, 12, and 24 hours, then once daily
- Tracking Notes
- Patient should be switched to oral ACT as soon as they can swallow medication.
- Body Weight
- 16-20 kg
- Dose
- 48 mg to 60 mg
- Frequency
- At 0, 12, and 24 hours, then once daily
- Tracking Notes
- Dosing transitions to 2.4 mg/kg for body weights above 20 kg.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 15 mg (calculated at 3 mg/kg) | At 0, 12, and 24 hours, then once daily | Administer intravenously or intramuscularly under strict hospital supervision. |
| 5-7 kg | 15 mg to 21 mg | At 0, 12, and 24 hours, then once daily | Based on the pediatric dosing guideline of 3 mg/kg. |
| 8-10 kg | 24 mg to 30 mg | At 0, 12, and 24 hours, then once daily | Ensure complete dissolution of the injection vial using the provided solvent. |
| 11-15 kg | 33 mg to 45 mg | At 0, 12, and 24 hours, then once daily | Patient should be switched to oral ACT as soon as they can swallow medication. |
| 16-20 kg | 48 mg to 60 mg | At 0, 12, and 24 hours, then once daily | Dosing transitions to 2.4 mg/kg for body weights above 20 kg. |
Formulation
Purpose
Treatment of severe malaria and acute uncomplicated malaria caused by Plasmodium falciparum strains.
Generic Name
ArtesunateScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.