Orfiril
Orfiril is an anticonvulsant and mood-stabilizing medication containing sodium valproate. It works by increasing brain levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which helps to prevent seizures and stabilize mood in bipolar disorder.
Dosage by Body Weight
Dosage must be individualized and determined strictly by a physician. Typically initiated at 10-15 mg/kg body weight daily, then increased gradually to an optimal maintenance dose of 20-30 mg/kg daily. Monitor liver function and blood counts regularly during therapy.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy in infants under this weight must be assessed individually by a pediatric neurologist.
- Body Weight
- 5-7 kg
- Dose
- 75 mg to 150 mg daily
- Frequency
- Divided into 2 doses
- Tracking Notes
- Usually administered using oral syrup formulation. Titrate under strict medical guidance.
- Body Weight
- 8-10 kg
- Dose
- 120 mg to 300 mg daily
- Frequency
- Divided into 2 doses
- Tracking Notes
- Monitor response and plasma concentrations if control is difficult to achieve.
- Body Weight
- 11-15 kg
- Dose
- 150 mg to 450 mg daily
- Frequency
- Divided into 1 to 2 doses
- Tracking Notes
- Prolonged-release forms (Orfiril Long) may be used if the child can swallow or if the mini-tablets are mixed with soft food.
- Body Weight
- 16-20 kg
- Dose
- 240 mg to 600 mg daily
- Frequency
- Divided into 1 to 2 doses
- Tracking Notes
- Dose adjustment should be done slowly over several days to minimize gastrointestinal side effects.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Safety and efficacy in infants under this weight must be assessed individually by a pediatric neurologist. |
| 5-7 kg | 75 mg to 150 mg daily | Divided into 2 doses | Usually administered using oral syrup formulation. Titrate under strict medical guidance. |
| 8-10 kg | 120 mg to 300 mg daily | Divided into 2 doses | Monitor response and plasma concentrations if control is difficult to achieve. |
| 11-15 kg | 150 mg to 450 mg daily | Divided into 1 to 2 doses | Prolonged-release forms (Orfiril Long) may be used if the child can swallow or if the mini-tablets are mixed with soft food. |
| 16-20 kg | 240 mg to 600 mg daily | Divided into 1 to 2 doses | Dose adjustment should be done slowly over several days to minimize gastrointestinal side effects. |
Formulation
Purpose
Treatment of epilepsy (generalized, partial, or other seizures) and manic episodes associated with bipolar disorder.
Generic Name
Sodium ValproateScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.