Khapzory
Khapzory (levoleucovorin) is a folate analog. It is the pharmacologically active isomer of leucovorin (folinic acid) used to rescue healthy cells from the toxic effects of high-dose methotrexate and to treat accidental methotrexate overdoses, as well as in combination regimens for advanced colorectal cancer.
Dosage by Body Weight
Administered exclusively via intravenous infusion. Dosing is highly complex and must be individualized based on chemotherapy protocols, body surface area (BSA), and serum methotrexate levels. Always consult an oncologist.
- Body Weight
- Below 5 kg
- Dose
- Highly individualized
- Frequency
- As directed by oncologist
- Tracking Notes
- Dosed based on Body Surface Area (BSA) and blood methotrexate levels. Not for routine home use.
- Body Weight
- 5-7 kg
- Dose
- Highly individualized
- Frequency
- As directed by oncologist
- Tracking Notes
- Dosed based on Body Surface Area (BSA) and blood methotrexate levels. Not for routine home use.
- Body Weight
- 8-10 kg
- Dose
- Highly individualized
- Frequency
- As directed by oncologist
- Tracking Notes
- Dosed based on Body Surface Area (BSA) and blood methotrexate levels. Not for routine home use.
- Body Weight
- 11-15 kg
- Dose
- Highly individualized
- Frequency
- As directed by oncologist
- Tracking Notes
- Dosed based on Body Surface Area (BSA) and blood methotrexate levels. Not for routine home use.
- Body Weight
- 16-20 kg
- Dose
- Highly individualized
- Frequency
- As directed by oncologist
- Tracking Notes
- Dosed based on Body Surface Area (BSA) and blood methotrexate levels. Not for routine home use.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Highly individualized | As directed by oncologist | Dosed based on Body Surface Area (BSA) and blood methotrexate levels. Not for routine home use. |
| 5-7 kg | Highly individualized | As directed by oncologist | Dosed based on Body Surface Area (BSA) and blood methotrexate levels. Not for routine home use. |
| 8-10 kg | Highly individualized | As directed by oncologist | Dosed based on Body Surface Area (BSA) and blood methotrexate levels. Not for routine home use. |
| 11-15 kg | Highly individualized | As directed by oncologist | Dosed based on Body Surface Area (BSA) and blood methotrexate levels. Not for routine home use. |
| 16-20 kg | Highly individualized | As directed by oncologist | Dosed based on Body Surface Area (BSA) and blood methotrexate levels. Not for routine home use. |
Formulation
Purpose
Used as a rescue therapy to prevent or decrease toxic effects of high-dose methotrexate treatment, to treat accidental methotrexate overdose, and in combination with fluorouracil to treat metastatic colorectal cancer.
Generic Name
LevoleucovorinScheduled Drug
No. This medicine is generally not treated as a scheduled/prescription-only drug in common consumer references, but local rules may vary.