Doluvir
Doluvir contains Dolutegravir, an integrase strand transfer inhibitor (INSTI). It works by preventing the HIV virus from replicating and multiplying, thereby reducing the viral load in the blood and supporting the immune system.
Dosage by Body Weight
For adults and adolescents weighing at least 30 kg, the standard dose is 50 mg (one tablet) taken orally once daily, with or without food. In cases of integrase inhibitor resistance or co-administration with certain drugs like rifampin, the dose may be increased to 50 mg twice daily. Pediatric doses are determined by body weight.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy are not established for infants weighing less than 3 kg. Consult a pediatric HIV specialist.
- Body Weight
- 5-7 kg
- Dose
- 5 mg
- Frequency
- Once daily
- Tracking Notes
- Typically administered using dispersible tablet formulations.
- Body Weight
- 8-10 kg
- Dose
- 10 mg
- Frequency
- Once daily
- Tracking Notes
- Administered preferably as dispersible tablets.
- Body Weight
- 11-15 kg
- Dose
- 15 mg
- Frequency
- Once daily
- Tracking Notes
- Dispersible tablets are preferred. Regular film-coated tablets can be used if the child can safely swallow them.
- Body Weight
- 16-20 kg
- Dose
- 20 mg
- Frequency
- Once daily
- Tracking Notes
- Dosing should be monitored closely by a healthcare provider. Dispersible or standard formulations can be used.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Safety and efficacy are not established for infants weighing less than 3 kg. Consult a pediatric HIV specialist. |
| 5-7 kg | 5 mg | Once daily | Typically administered using dispersible tablet formulations. |
| 8-10 kg | 10 mg | Once daily | Administered preferably as dispersible tablets. |
| 11-15 kg | 15 mg | Once daily | Dispersible tablets are preferred. Regular film-coated tablets can be used if the child can safely swallow them. |
| 16-20 kg | 20 mg | Once daily | Dosing should be monitored closely by a healthcare provider. Dispersible or standard formulations can be used. |
Formulation
Purpose
Used in combination with other antiretroviral medications for the treatment of Human Immunodeficiency Virus type 1 (HIV-1) infection.
Generic Name
DolutegravirScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.