Dolutegravir (Pediatric)
An Integrase Strand Transfer Inhibitor (INSTI). It has a high genetic barrier to resistance and is now the WHO-preferred first-line treatment for children.
Dosage by Body Weight
Dispersible tablets (5mg) are used for infants/children from 3kg and 4 weeks of age. Can be dissolved in water.
- Body Weight
- 3-6 kg
- Dose
- 5 mg
- Frequency
- Once daily
- Tracking Notes
- Preferred 5mg dispersible tablet for infants.
- Body Weight
- 14-20 kg
- Dose
- 25 mg
- Frequency
- Once daily
- Tracking Notes
- Can be taken with or without food.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| 3-6 kg | 5 mg | Once daily | Preferred 5mg dispersible tablet for infants. |
| 14-20 kg | 25 mg | Once daily | Can be taken with or without food. |
Formulation
Purpose
First-line antiretroviral treatment for HIV-1.
Generic Name
Dolutegravir (DTG)Branded Drug Names
Dolutegravir (Pediatric) is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.
Alternatives
Safety Advice
Alcohol
CAUTIONDolutegravir (Pediatric): Alcohol may worsen dizziness, nausea, dehydration, or liver strain during antiviral treatment. Avoid or limit alcohol.
Pregnancy
SAFE IF PRESCRIBEDDolutegravir (Pediatric): Use during pregnancy only when prescribed; treatment may be important for maternal infection control or prevention of transmission.
Breast Feeding
SAFE IF PRESCRIBEDDolutegravir (Pediatric): Breastfeeding advice depends on the infection and treatment regimen. Use only with healthcare provider guidance.
Driving
CAUTIONDolutegravir (Pediatric): May cause dizziness, fatigue, sleep disturbance, or headache. Avoid driving if alertness is affected.
Liver
CAUTIONDolutegravir (Pediatric): Some antivirals can affect liver function or require monitoring in hepatitis, HIV, or severe illness.
Kidney
CAUTIONDolutegravir (Pediatric): Several antivirals are cleared by the kidneys and may need dose adjustment or hydration. Consult your healthcare provider.