Diflucan
Diflucan (fluconazole) is a synthetic triazole antifungal agent. It works by inhibiting the fungal cytochrome P450 enzyme, preventing the synthesis of ergosterol, an essential component of fungal cell membranes.
Dosage by Body Weight
Standard adult dose is 150 mg as a single oral dose for vaginal candidiasis. For other infections, typical adult doses range from 100 mg to 400 mg daily. Pediatric doses are highly dependent on body weight and the specific type of fungal infection, typically ranging from 3 mg/kg to 12 mg/kg once daily.
- Body Weight
- Below 5 kg
- Dose
- 12 mg to 30 mg (Based on 3-6 mg/kg)
- Frequency
- Once daily (or every 48 to 72 hours for neonates)
- Tracking Notes
- Must be prescribed and calculated precisely by a pediatrician. Clearance is significantly slower in newborns.
- Body Weight
- 5-7 kg
- Dose
- 15 mg to 42 mg (Based on 3-6 mg/kg)
- Frequency
- Once daily
- Tracking Notes
- Dosage may be increased up to 12 mg/kg/day (84 mg maximum for this weight range) for severe systemic infections under specialist guidance.
- Body Weight
- 8-10 kg
- Dose
- 24 mg to 60 mg (Based on 3-6 mg/kg)
- Frequency
- Once daily
- Tracking Notes
- Commonly administered as oral suspension. Shake well before use.
- Body Weight
- 11-15 kg
- Dose
- 33 mg to 90 mg (Based on 3-6 mg/kg)
- Frequency
- Once daily
- Tracking Notes
- Dosage may be increased up to 12 mg/kg/day (180 mg maximum for this weight range) for serious systemic conditions.
- Body Weight
- 16-20 kg
- Dose
- 48 mg to 120 mg (Based on 3-6 mg/kg)
- Frequency
- Once daily
- Tracking Notes
- Ensure precise measurement using a dosing syringe or cup for liquid formulations. Maximum pediatric dose must not exceed adult limits (typically 600 mg/day).
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 12 mg to 30 mg (Based on 3-6 mg/kg) | Once daily (or every 48 to 72 hours for neonates) | Must be prescribed and calculated precisely by a pediatrician. Clearance is significantly slower in newborns. |
| 5-7 kg | 15 mg to 42 mg (Based on 3-6 mg/kg) | Once daily | Dosage may be increased up to 12 mg/kg/day (84 mg maximum for this weight range) for severe systemic infections under specialist guidance. |
| 8-10 kg | 24 mg to 60 mg (Based on 3-6 mg/kg) | Once daily | Commonly administered as oral suspension. Shake well before use. |
| 11-15 kg | 33 mg to 90 mg (Based on 3-6 mg/kg) | Once daily | Dosage may be increased up to 12 mg/kg/day (180 mg maximum for this weight range) for serious systemic conditions. |
| 16-20 kg | 48 mg to 120 mg (Based on 3-6 mg/kg) | Once daily | Ensure precise measurement using a dosing syringe or cup for liquid formulations. Maximum pediatric dose must not exceed adult limits (typically 600 mg/day). |
Formulation
Purpose
Used to treat and prevent various fungal and yeast infections, most notably vaginal, oral, esophageal, and systemic candidiasis, as well as cryptococcal meningitis.
Generic Name
FluconazoleScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.